摘要
目的 探讨Fisher综合征的临床特点 ,加深对本病的认识。方法 对 8例Fisher综合征临床资料进行分析 ,并综合文献 ,阐述该病的临床特点及发病机制、治疗方法。结果 Fisher综合征好发于青壮年 ,急性起病 ,以眼外肌麻痹、共济失调、腱反射减弱或消失为主要表现 ,是吉兰———巴雷综合征 (GBS)的特殊类型 ,不仅有周围神经的损害 ,可能还有脑干和小脑的病损 ,诊治不及时可转化为全身型GBS ,早期激素治疗有效。结论 根据临床特点 ,结合脑脊液常规、免疫学检查及肌电图、神经活检能早期确诊 ,头颅MRI有助诊断。
Objective To study the cause, clinical characteristics and therapy of Fisher syndrome.Methods The clinical manifestation, CSF, EMG, MRI and nerve biopsy of 8 patients, were analysed and reviewed with literature.Results Fisher syndrome developes acutely and, the highest incidence is in young adults.Patients present with ataxia, external ophthalmoplegia and areflexia.CSF protein may be elevated.MRI can detect lesions in cerebel or brainstem.The electrophysiology findings indicate a demyelinative neuropathy.There are inflammatory cells infiltrating and demyelinating in peripheral nerve biopsy.The disorder is often responsive to treatment with corticosteroids.Conclusion Fisher syndrome is a virant of Guillain Barre syndrome.The diagnosis depends on the clinical features and investigative studies.
出处
《卒中与神经疾病》
2001年第6期354-356,共3页
Stroke and Nervous Diseases
基金
国家自然科学基金资助项目 ( 39470 2 6 2 )
