摘要
目的 :比较尼莫通和 β 七叶皂甙钠分别使用及联用治疗高血压性脑出血术后患者的疗效。方法 :经CT证实的 6 0例急性高血压脑出血患者于发病第 2～ 5日手术 ,术后应用前瞻性随机单盲法分为 4组 ,每组 15例。 A组 :甘露醇 ;B组 :β七叶皂甙钠 +甘露醇 ;C组 :尼莫通 +甘露醇 ;D组 :β七叶皂甙钠 +尼莫通 +甘露醇 ,计算治疗 2周后神经功能缺损程度积分差及 1周后 CT最大层面脑水肿面积的差值 ,比较 4组疗效。结果 :与 A组比较 ,B、C 2组患者治疗 2周后神经功能缺损程度积分差及 1周后 CT最大层面脑水肿面积的差值均明显增多 (P均 <0 .0 1) ;但与 D组比较 ,差值则明显减少 (P<0 .0 5或 P<0 .0 1)。B、C2组比较 ,在脑水肿吸收程度上虽无显著差异 (P>0 .0 5 ) ,但在神经功能改善方面 C组积分差显著高于 B组 (P<0 .0 1)。结论 :尼莫通和β 七叶皂甙钠不仅能明显减轻脑水肿 ,且能促进神经功能恢复 ,两者虽在脑水肿吸收程度上无明显区别 ,但在促进神经功能恢复方面尼莫通优于 β 七叶皂甙钠 ,两者联用效果优于单独使用。
Objective:To compare the clinical therapeutic effect of nimotop and βaescine respectively and combinedly in the treatment of postoperation on acute hypertensive hemorrhage.Methods:With the prospective random single blind method,60 patients with acute hypertensive hemorrhage who were confirmed by CT scan were operated on 2nd to 5th day.They were randomly divided into four guoups after operation( n =15). A group :mannitol,B group:mannitol+βaescine,C group:mannitol+nimotop,D group:mannitol+βaescine+nimotop.The four groups were compared with the indexes of the score difference of neurological functional defect after two weeks and brain edema area difference on the maximum slice after one week of CT.Results:The average decreased score of neurological functional defect with treatment of group B or C and brain edema area difference on the maximum slice of CT were better than those in group A (all P <0.01),while compared to group D,the indexes in group B and C showed a marked decrease ( P <0 05 or P <0 01).There were no apparent significant difference in brain edema area absorption between B and C ( P >0 05),but the increase in group C were more significant than that in group B in the indexes of the score difference of neurological functional defect ( P <0 01).Conclusions:Nimotop and βaescine not only reduced brain edema but also promoted neurological function,the two groups had a similar distribution in brain edema area absorption,but nimotop promoted neurological function more effect than βaescine,and combined use of them show better effects than single.
出处
《中国中西医结合急救杂志》
CAS
2001年第6期362-364,共3页
Chinese Journal of Integrated Traditional and Western Medicine in Intensive and Critical Care
基金
河南省南阳市科委"九.五"科技攻关基金资助项目( No.982 0 0 3)
