摘要
目的 :了解雷公藤多甙治疗肾小球肾炎的机理。方法 :采用流式细胞术动态测定 37例IgA肾病患者雷公藤多甙治疗中尿液单个核细胞分布和CD44表达改变。结果 :IgA肾病患者尿液CD3+ 、CD4+ 、CD8+ 、CD14+ 、CD44 + 细胞密度均显著高于正常 ,CD4/CD8比值显著低于正常 ,雷公藤多甙治疗后尿液CD3+ 、CD4+ 、CD8+ 、CD14+ 和CD44 + 细胞密度均明显减少 ,CD4/CD8比值增高 ;治疗缓解组CD4+ 细胞百分率显著低于无效组 ,而CD14+ 细胞则显著高于无效组。结论 :雷公藤多甙可调节肾脏细胞免疫功能和粘附分子CD44表达 ,其治疗效果与肾脏免疫状态相关。
Objective:To study the possible therapeutic mechanisms of triptergium wilfordi in treating glomerulonephritis.Methods:Thirty seven patients with IgA nephropathy were detected urine mononeuclear cells densities with flow cytometry during taking triptergium wilfordi tablets,30 healthy people were used as normal control.Results:The patients urine CD3 +?CD4 +?CD8 +?CD14 + and CD44 + cells densities were much higher than normal control's,but obviously decreased after triptergium wilfordi treatment.CD4/CD8 ratio was much lower in patients than in normal control.It increased markedly after treatment.Patients who reached remission initially had a lower CD4 + cell percentage and higher CD14 + cells percentage than those showed no response to triptergium wilfordi treatment.Conclusion:Triptergium wilfordi could modulate kidney immune cell function and adhesive molecule CD44 expression.Its effects were associated with renal immunity.
出处
《中国免疫学杂志》
CAS
CSCD
北大核心
2001年第10期557-558,共2页
Chinese Journal of Immunology
