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西咪替丁治疗危重症新生儿并发上消化道出血42例

Cimetidine in treating upper alimentary canal hemorrhage after critical neonates in 42 cases
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摘要 目的:观察西咪替丁治疗危重症新生儿并发上消化道出血的疗效.方法:将83例患儿随机分为两组.两组均在积极治疗原发病的同时,给以1%碳酸氢钠洗胃,凝血酶400U经胃管注入胃内,每6 h一次,出血量多者输新鲜血.治疗组42例,在此基础上加用西咪替丁3~5mg/kg静滴,每6~8 h 1次.结果:治疗组总有效率为92.9%(39/42),对照组总有效率为70.7%(29/41),P<0.01.结论:西咪替丁治疗危重症新生儿并发上消化道出血疗效显著,未见明显副作用. Objective: To observe the efficacy of cimetidine in treating critical neonates complicated with upper alimentary canal hemorrhage. Methods: 83 cases of critical neonates complicated with upper alimentary canal hemorrhage were randomly divided into two groups, while treated the protopathy actively, two groups were washed out the stomach with 1 % dicarbonate, poured thrombin 400 unit into stomach through stomach tube and accepted metachysis in case of massive hemorrhage, cimtetidine group (n = 42) received cimetidine 3 ~ 5 mg/kg, iv drip, once every six to eight hours. Results: The total response rates of the control and cimetidine groups were 70. 7% and 92. 9% , respectively( P < 0. 01) . Conclusion: Cimetidine is efiective in treating upper alimentary canal hemorrhage alter critical neonates.
作者 霍开明
出处 《儿科药学》 2001年第3期26-27,共2页 Journal of Pediatric Pharmacy
关键词 西咪替丁 新生儿 消化道出血 药物治疗 危重症 Cimetidine Newborn Alimentary canal hemorrhage Traetment Critical illness
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