摘要
采用原子吸收分光光度法测定静脉给药后小鼠血浆和各脏器组织中卡铂的浓度 ,并对肺靶向卡铂明胶微球和游离药物卡铂的药物动力学、体内分布行为和肺靶向性进行了比较研究。结果表明卡铂明胶微球药物动力学模型为三室模型 。
To study the pharmacokinetics and tissue distribution of the carboplatin gelatin microspheres, the drug concentration of blood and tissues was determined by atomic absorption spectrophotometry(AAS). The concentration time curve of carboplatin gelatin microspheres conformed to the three compartments model. The concentration in the lung was much higher than that of carboplatin solution. The carboplatin microspheres were regarded as showing notable targeting efficacy.
出处
《中国医药工业杂志》
CAS
CSCD
北大核心
2001年第6期251-253,共3页
Chinese Journal of Pharmaceuticals
基金
国家自然科学基金资助项目 (No.3 9170 868)
关键词
卡铂
明胶微球
肺靶向给药系统
药物动力学
组织分布
carboplatin
gelatin microspheres
lung targeting drug delivery system
pharmacokinetics
tissue distribution
