摘要
目的 :探讨用于喉癌患者术后复发监测及预后评估的参考指标。方法 :对 34例喉癌患者 (喉癌组 )分别检测术前和术后第 7天、第 30天、第 90天的血清 IL- 2、s IL- 2 R、TNF- α水平。并以 2 0例健康人进行对照 (对照组 )。结果 :喉癌组术前的血清 s IL- 2 R与 TNF- α水平明显高于对照组 (P <0 .0 1) ,IL- 2两组无差异。随访 3个月 ,2 9例未复发患者 (未复发组 ) s IL- 2 R、TNF- α水平术后第 7天稍高于术前 ,但无统计学意义 ;术后第 30天和第 90天逐渐下降 ,其中 s IL- 2 R水平下降更为明显 ,IL- 2无明显变化。 5例复发患者 (复发组 ) s IL- 2 R、TNF- α水平术后第 30天低于术前 ,第 90天又升高 ;而 IL- 2则逐渐下降。结论 :检测喉癌患者手术前后的血清细胞因子的动态变化 ,对病情的监测及预后的判定有一定的参考价值。
Objective:To observe the dynamic changes of cytokines pre and postoperation in pateints with carcinoma of the larynx and provide reference for recurrence monitor and prognosis evaluation in postoperative patients with head and neck tumor.Method:Thirty four patients with head and neck squamous cell carcinoma were included in this study.Serum levels of IL 2、sIL 2R and TNF α were measured before surgery、7 days、30 days and 90 days after surgery with ELISA and RIA.Result:The serum levels of sIL 2R and TNF α before surgery in patients with carcinoma of the larynx were significantly elevated compared with controls(P< 0.01 ),while the level of IL 2 was not different.Serum concentrations of sIL 2R and TNF α in patients without recurrence found at 7 days after operation were slightly higher than those before operation,but there was not significant difference.Moreover,the levels of sIL 2R and TNF α at 30 days and 90 days postoperation decreased gradually,especialy the sIL 2R levels decreased more significantly.No statistical difference were found among serum IL 2 levels in non recurrence patients.The serum levles of sIL 2R and TNF α in patients with recurrence at 30 days after operation were lower than those befroe operation and increased at 90 days after operation,while the levels of IL 2 decreased gradually.Conclusion:Dynamic study of the cytokines pre and postoperation play reference role in recurrence monitor and prognosis evaluation after the larynx carcinoma were removed.
出处
《临床耳鼻咽喉科杂志》
CSCD
北大核心
2001年第6期255-257,共3页
Journal of Clinical Otorhinolaryngology
