摘要
利用循环伏安、紫外可见光谱电化学、荧光光谱电化学、圆二色光谱电化学等方法研究了阿霉素（ＡＤＭ）在石墨电极上的电化学行为．结果发现，阿霉素在＋０．２～＋０．７Ｖ和－０．２～－０．７Ｖ范围内分别出现一对氧化还原峰．正电位下，蒽环上的酚羟基发生单电子氧化，并伴随后续化学反应．负电位范围内，阿霉素经历ＥＣＥ电极反应过程，即蒽醌经单电子还原生成半醌自由基，半醌可发生不可逆的化学反应，脱去配氧糖基，转变为７－去氧柔毛霉醌（７－ｄｅｏｘｙａｄｒｉａｍｙｃｉｎｏｎｅ）。
The electrochemical behavior of Adriamycin(ADM) at graphite electrode has been investigated by spectroelectrochemistry and cyclic voltammetry. The electrode reaction mechanism of ADM at different potentials has been described. In the positive potential range, a oneelectron transfer occurs accompanied with a consequent chemical reaction, corresponding to oxidation of hydroquinone functionality to the quinone. At negative potential, Adriamycin involves in a reversible oneelectron reduction producing semiquinone species, the latter undergoes a subsequent irreversible chemical reaction with elimination of the glycoside, giving the 7deoxyadriamycinone, which could be reversibly reduced at more negative potentials. The ECE mechanism has been proposed to explain the electrode reduction process.
出处
《高等学校化学学报》
SCIE
EI
CAS
CSCD
北大核心
1999年第6期866-871,共6页
Chemical Journal of Chinese Universities
基金
国家自然科学基金
