摘要
目的 探讨胎盘型谷胱甘肽S转移酶 (GST π)的表达与胃黏膜肠化生及其增殖状态分型、硫酸化黏液分泌状况的关系。方法 采用免疫组织化学方法检测 16 7例胃黏膜活检及外科手术标本中GST π的表达 ,并对 112例伴肠化生慢性萎缩性胃炎作免疫组化和黏液组化套染 ,进行肠化生增殖状态分型。结果 胃腺癌、伴异型增生慢性萎缩性胃炎和伴肠化生慢性萎缩性胃炎中GST π的阳性率均显著高于慢性浅表性胃炎 ,但伴异型增生慢性萎缩性胃炎与胃腺癌中GST π的阳性率无明显差异。GST π的阳性率与肠化生细胞是否分泌硫酸黏液无关 ;高增殖型肠化生中GST π的阳性率显著高于中、低增殖型肠化生。结论 提示GST π是一种较好的胃癌前病变标志物 。
Objective To explore the correlation of the expression of glutathione S transferase (GST) π with intestinal metaplasia as well as its proliferative typing, and secretary state of vitriolic mucus in the gastric mucosa. Methods Immunohistochemical method was used to detect the expression of GST π in 167 cases of gastroscopic biopsy of the mucosa or surgical removed gastric specimens. Both mucus histochemical and immunohistochemical methods was applied to identify the subtypes of proliferative activity in 112 cases of chronic atrophy gastritis (CAG) with intestinal metaplasia. Results Expression of GST π was significantly higher in gastric adenocarcinoma and CAG with intestinal metaplasia or/and dysplasia than in chronic superficial gastritis. There was no apparent difference between gastric adenocarcinoma and CAG with dysplasia. Expression of GST π was not related to the secretion of vitriolic mucus in the mucosa with intestinal metaplasia. The positive rate of GST π staining was significantly higher in the high proliferative type (HPT)than in lower and medium proliferative types of CAG with intestinal metaplasia. Conclusions GST π is a good marker for precancerous lesion of the stomach. CAG with HPT is highly correlated with occurrence of gastric cancer.
出处
《诊断病理学杂志》
CSCD
2001年第2期93-95,I029,共4页
Chinese Journal of Diagnostic Pathology
关键词
谷胱甘肽S转移酶
肠化生
增殖细胞核抗原
胃黏膜
GST π
Intestinal metaplasia
Proliferating cell nuclear antigen
Gastric mucosa
