摘要
目的 :研究复方骨质增生贴剂 (CPH)的经皮吸收的可行性。方法 :采用高效液相色谱法测定透皮接受液和释放接受液中指标成分—阿魏酸的浓度。结果 :体外透皮实验和体外释放实验结果表明 :阿魏酸在 2 4h内以一定的速率 0 .2 142μg·cm-2 ·h-1恒速渗透 ,其释放符合Higuchi方程。此外 ,该贴剂的体外释放速率为 14.5 3μg·cm-2 ·h-1/ 2 。结论
Objective: To study the feasibility of percutaneous absorption of Compound Patch of Hyperosteogeny(CPH). Methods: The content of ferulic acid,an index composition in percutaneous receptor fluid and release receptor fluid were determined by HPLC.Results: The results of in vitro transdermal delivery experiment and in vitro release experiment showed that ferulic acid permeated at the constant speed of 0.2142μg·cm -2 ·h -1 in 24 hours and its release coincided with Higuchi Equation.Futhermore,the release rate was 14.53μg·cm -2 ·h -1/2 . Conclusion: CPH is a skeleton controlledtransdermal delivery system whose permeation speed is limited by skin.
出处
《中成药》
CAS
CSCD
北大核心
2001年第4期237-240,共4页
Chinese Traditional Patent Medicine
