摘要
目的 对比 10mg、2 0mg两种剂量辛伐他汀治疗老年高血脂症疗效和安全性。方法 服用辛伐他汀10mg组 ,10mg/d ;2 0mg组 ,2 0mg/d ;均为晚上顿服 ,服药 2～ 4周随诊 1次 ,观察临床症状 ,发生心脏事件情况 ,心功能 ,不良反应 ,并测血压、心率、体重等 ,服药后 1、3、6个月查血脂 ,血、尿常规 ,血糖 ,肝功能 ,血尿酸。结果 ①治疗 6个月后两组TC、TG、LDL -C、ApoB明显降低 (两组治疗前后比较均P <0 0 1) ;②治疗两组间比较 ,2 0mg组降TC、TG、LDL -C显著优于 10mg组 ,均P <0 0 1;③达标率 10mg组TC、TG、LDL -C达标率分别为 4 6 8%、59 6 %和 53 1% ,2 0mg组分别为 75 4 %、83%和 77 4 % ,两组间比较 3项指标均有显著性差异 ;④两组治疗期间发生心脏性事件 ,2 0mg组比 10mg组的危险性下降 ;⑤两组安全性无明显差异。结论 治疗高血脂症、预防心脏事件 ,2 0mg/d更适合。
Objective To compare the curative effects and safety of cinchotadine on senile hyperlipemia in different dosages. Methods The patients were given the drug in 10mg/d and 20mg/d separately every night for 2～4 weeks with follow-up. The clinical symptoms and signs and manifestations were recorded including routine test of blood and urine, blood sugar, liver function and so on after treatment at 1, 3 and 6 months. Results TC, TG, LDL-C and ApoB were significantly decreased than those before treatment in both groups (P<0.01). The decreased degree of TC, TG and LDL-C was better than those in 10mg group (P<0.01). The acceptable rates of TC, TG and LDL-C were 46.8%, 59.6% and 53.1% in 10mg group and 75.4%, 83% and 77.4% in 20mg group. There were significantly differences between two groups in TC, TG and LDL-C. The risk of cardiac attack during treatment of 20mg group was lower than that of 10mg group and the safety of two groups was similar. Conclusion The treatment of this drug in 20mg/d could be available for hyperlipemia and could prevent cardiac attack so that should be used widely.
出处
《黑龙江医学》
2001年第4期252-253,共2页
Heilongjiang Medical Journal
