摘要
目的:分析丹参注射液对2型糖尿病下肢血管病变患者部分炎性指标的影响。方法:收集2型糖尿病患者150例,100例合并下肢血管病变,随机分为丹参注射液组和传统治疗组,其余50例不合并下肢血管病变为对照组;丹参注射液组为传统治疗加丹参注射液,传统治疗组为传统治疗;对比下肢血管病变者和对照组血清C反应蛋白(CRP)、白细胞介素6(IL-6)水平,治疗后对比丹参注射液组和传统治疗组CRP和IL-6的变化。结果:下肢血管病变者CRP和IL-6显著高于对照组(P<0.05),治疗后丹参注射液组CRP和IL-6水平显著低于传统治疗组(P<0.05);丹参注射液组总有效率显著高于传统治疗组(P<0.01)。结论:丹参注射液可降低患者CRP和IL-6水平,对2型糖尿病合并下肢血管病变的患者效果较好。
Objective： To analyze the effect of salvia miltiorrhiza injection on inflammatory indicators of type 2 diabetes patients with lower extremity vascular disease. Methods： 150 patients with type 2 diabetes were selected, 100 patients combined with lower extremity vascular disease were randomly divided into salvia miltiorrhiza injection treatment group and traditional treatment group, the remaining 50 cases without lower extremity vascular disease as control group; salvia miltiorrhiza injection group was given traditional treatment and salvia miltiorrhiza injection, the traditional treatment group was given traditional treatment; Comparing the serum C reactive protein （CRP） and interleukin 6 （IL-6） levels between lower extremity vascular disease and control group. After the treatment, comparing the changes of CRP and IL-6 in salvia miltiorrhiza injection group and traditional treatment group. Results： Vascular lesions in the lower extremity of CRP and IL-6 was higher than that in control group （P〈0.05）, after treatment, in salvia miltiorrhiza injection group, the levels of CRP and IL-6 decreased which were lower than that in the traditional treatment group （P〈0.05）; the total effective rate of salvia miltiorrhiza injection group was higher than that of traditional treatment group （P〈0.01）. Conclusion： Salvia miltiorrhiza injection can decrease CRP and IL-6 levels in patients, and had a significant effect on the type 2 diabetes patients with lower extremity vascular disease.
出处
《中华中医药杂志》
CAS
CSCD
北大核心
2014年第6期2061-2062,共2页
China Journal of Traditional Chinese Medicine and Pharmacy
作者简介
通讯作者：黄倩，河北省沧州市中心医院内分泌科，邮编：061001，电话：0317—2075753，E—mail：betty0322cn@163．com
