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Cystatin C与恶性肿瘤的关系 被引量:4

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摘要 浸润及转移是恶性肿瘤的特征性表现,肿瘤细胞能产生多种水解酶(如半胱氨酸蛋白酶,无花果蛋白酶等)降解细胞外基质,破坏宿主黏膜屏障。近年来,研究人员发现半胱氨酸蛋白酶抑制剂C(Cystatin C)能有效的抑制细胞内外的半胱氨酸蛋白酶的活性,从而间接抑制肿瘤的浸润转移,因此有望成为肿瘤检测及治疗的分子指标。
作者 何琳莉 文彬
出处 《川北医学院学报》 CAS 2014年第3期243-246,共4页 Journal of North Sichuan Medical College
基金 四川省科技厅科研项目(sz0258)
作者简介 何琳莉(1989-),女,四川南充人,硕士研究生,主要从事胃肠道肿瘤病理方面的研究工作。 通讯作者:文彬,E-mail:wenbin662588@sina.com
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  • 1Anastasi A, Brown MA, Kembhavi AA, et al. Cystatin, a protein in- hibitor of cysteine proteinases: improved purification from eggWhite, characterization, and detection in chicken serum[J]. Bio Chem J,1983,211(1) :129 - 138.
  • 2Turk V, Bode W. The eystatins: protein inhibitors of eysteine pro- teinases[ J]. FEBS Left, 1991,285 (2) :213 - 219.
  • 3Staniforth RA, Giannini S, Higgins LD, et al. Three-dimensional domain swapping in the folded and molten-globule states of cyst- atins,an amyloid-forming structural superfamily [ J]. EMBO J, 2001,20( 17 ) :4774 - 4781.
  • 4侯振江.胱抑素C及其在肾脏疾病中的应用价值[J].中国微循环,2008,12(2):126-128. 被引量:38
  • 5Ishiguro H, Ohkubo I, Mizokami M, et al. The use of monoclonal antibodies to define levels of cystain C in normal human serum [J]. Hyridoma,1989,8(3) :303 -313.
  • 6Dickinson DP. Cysteine peptidases of mammals: their biological roles and potential effects in the oral cavity and other tissues in health and disease [ J ]. Crit Rev Oral Biol Med, 2002,13 ( 3 ) : 238 - 275.
  • 7Gocheva V, Zeng W, Ke D, et al. Distinct roles for eysteine eathep- sin genes in multistage tumorigenesis [ J ]. Genes Dev, 2006, 20 (5) :543 -556.
  • 8Hansen T, Unger RE, Gaumann A, et al. Expression of matrix-de- grading eysteine proteinase eathepsin K in eholesteatoma[ J]. Mod Pathol,2001,14(12) :1226 - 1231.
  • 9Nomura T, Katunuma N. Involvement of cathepsins in the invasion, metastasis and proliferation of cancer cells [ J]. J bled Invest, 2005,52(1 -2):1-9.
  • 10Dohehin A, Suzuki JI, Seki H, et al. Immunostained eathepsins B and L correlate with depth of invasion and different metastatic pathways in early stage gastric carcinoma [ J ]. Cancer, 2000,89 (3) :482 -487.

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