摘要
前处理过程是整个食品安全检测过程中最耗时耗力,最繁琐,并且最影响检测结果的一环。开发高效快速省时省力的前处理方法是未来的研究方向。本文建立基质辅助激光解吸电离飞行时间质谱(MALDI-TOF-MS)技术快速筛选牛奶中25中氟喹诺酮类药物残留的方法。将样品和基质混合点于靶板之上,直接进入基质辅助激光解吸电离飞行时间质谱进行测定,省去了繁琐的前处理过程。当牛奶中氟喹诺酮类药物残留量超过0.05 mg/kg时,可以有效检测到25种氟喹诺酮类药物残留中的18种。
Pretreatment process was considered as the most time/power consuming and complicated step in food safety analysis. Development of new efficient time-saving pretreatment method will be the future goal. In this paper, a quick screening method based on MALDI-TOF-MS was developed to detect 25 fluoroquinolone drugs in milk. Sample and matrix were mixed together and spotted onto a MALDI plate, without further treatment, it canbe directly analyzed by a MALDI-TOF-MS equipment. Eighteen fluoroquinolone drugs （among the 25 ） were detected by the method with a drug concentration over 0.05 mg/kg.
出处
《食品研究与开发》
CAS
北大核心
2013年第23期52-56,共5页
Food Research and Development
基金
山东出入境检验检疫局科研项目(SK201130)
作者简介
张金玲（1974-），女（汉），兽医师，兽医硕士，研究方向：食品检验。
通信作者：张启迪（1975-），男，副教授，主要从事药理学研究。
