摘要
目的探讨天津市1992—2010年新生儿乙型肝炎(乙肝)疫苗免疫策略的效果和经济效益。方法以天津市疾病预防控制中心历年计划免疫报告资料和血清学监测结果为基础,借助社区大规模乙肝及相关疾病监测,以乙肝及相关疾病患者为经济负担调查对象,运用成本效益分析方法进行综合评价。结果现行乙肝疫苗免疫接种的策略下,天津市20岁以下人群报告发病率由14.14/10万(1992年)下降到9.46/10万(2010年),下降幅度达33.00%。1992—2010年共减少HBsAg携带者98 984例,慢性乙肝17 830例,乙肝肝硬化5310例,肝癌1606例。共产出效益473.51亿元,净效益473.12亿元,效益成本比为1213∶1。结论天津市实施儿童乙肝疫苗免疫策略可获得巨大经济效益和社会效益。
Objective To investigate the effectiveness and economic benefits of the immunization strategy of infant hepatitis B vaccination implemented in Tianjin from 1992 to 2010. Methods The related data were collected from hepatitis B vaccine im-munization reports and serological surveillance results from Tianjin Center for Disease Control and Prevention, and from a large-scale community surveillance of hepatitis B and HBV-related diseases. Patients with hepatitis B and HBV-related diseases were the subjects of economic burden investigation. Cost-benefit analysis method was used to make a comprehensive evaluation of the immu-nization strategy. Results Under the present immunization strategy, the reported morbidity of the population aged younger than 20 in Tianjin decreased by 33.00%from 14.14/100 000 in 1992 to 9.46/100 000 in 2010. The number of patients with HBsAg positives decreased by 98 984 cases, the number of patients with chronic hepatitis B decreased by 17 830 cases, the number of patients with HBV-related liver cirrhosis decreased by 5310 cases, and the number of patients with liver cancer decreased by 1606 cases. The total benefit was 47.351 billion yuan, and the net benefit was 47.312 billion yuan with a benefit/cost ratio of 1213∶1. Conclusion The current immunization strategy of infant hepatitis B vaccination implemented in Tianjin acquires huge economic and social benefits.
出处
《传染病信息》
2014年第2期89-92,共4页
Infectious Disease Information
基金
天津市卫生局科技基金面上项目(2012KY14)
关键词
肝炎
乙型
慢性
乙型肝炎疫苗
免疫接种
加强
hepatitis B,chronic
hepatitis B vaccines
immunization,secondary
作者简介
[通讯作者】何海艳，E-mail：haiyanheqq@126．com
