摘要
目的探讨帕利哌酮联合碳酸锂治疗对双相障碍稳定期患者认知功能的影响。方法 60例稳定期双相障碍I型患者分成两组,分别是帕利哌酮缓释片联合碳酸锂治疗组30例,碳酸锂单药治疗组30例。采用修订韦氏成人记忆量表(WMSRC)、记忆广度(MS)、威斯康星卡片分类测验(WCST),比较组间认知、记忆和执行功能的差异。结果帕利哌酮联合碳酸锂治疗组在WCST卡片总数(t=3.83,P=0.000)、持续错误(t=2.19,P=0.039)、随机错误(t=3.68,P=0.000)、WMS-RC总分(t=2.27,P=0.020)、记忆商数(t=4.10,P=0.000)、数字广度(t=2.11,P=0.031)测评中均优于碳酸锂单药组。结论帕利哌酮联合碳酸锂治疗可能有助于缓解和改善双相障碍患者的认知功能。
[ Objective ] To investigate the effects of Paliperidone combined Lithium carbonate on cognitive function of patients with bipolar disorder. [ Methods ] 30 patients with lithium carbonate, 30 patients with Paliperidone combined Lithium carbonate. Patients were assessed with WMS-RC, MS, WCST to evaluate cognitive function, the differences between groups were compared. [ Results ] There were significant differences in number of total WCST tests（t=3.83, P=0.000）,number of persisting errors（t=2.19, P=0.039）,number of random errors（t=3.68, P=0.000）, total points of WMS-RC（t=2.27, P=0.020）,MQ（t=4.10, P=0.000）,digital span（t=2.11,P=0.031） between the groups. [ Conclusion ] The combination therapy of Paliperidone and Lithium carbonate has better effects on cognitive function of these patients with bipolar disorder.
出处
《中国医学工程》
2014年第3期11-11,13,共2页
China Medical Engineering
基金
佛山市医学类科技攻关项目(201308047)
关键词
帕利哌酮
双相障碍
碳酸锂
认知功能
Paliperidone
bipolar disorder
Lithium carbonate
cognitive function
