摘要
目的:观察颈动脉支架置入术治疗的老年患者应用依达拉奉减轻脑血管痉挛的疗效。方法:选取88例接受颈动脉支架置入术治疗的老年患者,按治疗方案不同分为两组:对照组46例,予以常规治疗;研究组42例,在常规治疗基础上予以依达拉奉治疗。治疗3周后,比较两组的迟发性脑血管痉挛(DCVS)发生率、日常生活能力(ADL)分值、临床神经功能缺损评分标准(CSS)分值以及大脑中动脉(MCA)血流速度的差异。随访1年,比较两组患者的格拉斯哥预后评分(GOS)差异。结果:与对照组比较,研究组的DCVS发生率、ADL分值、CSS分值以及MCA血流速度显著较优(P<0.05)。随访1年,研究组患者的恢复良好及轻度残疾比例显著高于对照组(P<0.05),且研究组的死亡率显著较低(P<0.05)。结论:依达拉奉能显著减轻接受颈动脉支架置入术治疗的老年患者的脑血管痉挛,改善预后。
OBJECTIVE： To observe the clinical efficacy of edaravone on cerebral vasospasm in elderly patients with carotid ar- tery stent implantation. METHODS： 88 elder patients with carotid artery stent implantation were chosen and divided into 2 groups. Control group received conventional therapy （46 cases）; research group received edaravone based on conventional therapy （42 cas- es）. After 3 weeks of therapy, the incidence of delayed cerebral vasospasm （DCVS）, activities of daily living （ADL）, clinical nerve function defect score （CSS） and the blood flow velocity of medial cerebral artery （MCA） were compared between 2 groups. By one year follow-up, the difference of Glasgow outcome scale （GOS） were compared between 2 groups. RESULTS： The inci- dence of DCVS, ADL, CSS and the blood flow velocity of MCA in research group were obviously better than in control group （P〈0.05）. By one year follow-up, the proportion of good recovery and mild disability in research group were significantly higher than in control group（P〈0.05）, and the incidence rates of death were lowered significantly in research group （P〈0.05）. CON- CLUSIONS： Edaravone can alleviate the degree of cerebral vasospasm in elder patients .with carotid artery stent implantation signifi- cantly and also can improve the prognosis.
出处
《中国药房》
CAS
CSCD
2014年第18期1680-1682,共3页
China Pharmacy
关键词
依达拉奉
颈动脉支架置入术
脑血管痉挛
老年
临床疗效
Edaravone
Carotid artery stent implantation
Cerebral vasospasm
Elder patients
Clinical efficacy
作者简介
主治医师。研究方向：脑血管病、神经介入。电话：0574—83009065。E-mail：zhangmmmm@126．com
通信作者：主任医师。研究方向：神经病学、脑血管病及介入。E-mail：dxpl725@163．com
