摘要
成人迟发型自身免疫性糖尿病（LADA）是成人发病的缓慢进展的自身免疫性糖尿病，其起病特点与2型糖尿病（T2DM）相似，占我国新诊断T2DM患者的5．9％～9．2％。LADA的发病机制是近年来研究热点之一，在遗传易感基因、自身免疫反应以及环境因素等方面的研究取得了一定进展，发现非人类白细胞抗原基因（HLA）、细胞免疫和非特异性免疫反应等与LADA有关。深人研究LADA的发病机制有助于阐明LADA发病和临床特点，对疾病的早期预防和诊断、合理治疗以及探索新的治疗方法等均有积极作用。
Latent autoimmune diabetes in adults （LADA） is a form of adult-onset autoimmune diabetes that resembles type 2 diabetes. However, it shows a later onset and slowly progression towards insulin requirement. LADA accounts for 5.9% to 9.2% in newly diagnosed patients with phenotypic type 2 diabetes in China. The pathogenesis of LADA has become one of the hot research topics in recent years. Progresses have been made in aspects such as genetic susceptibility, autoimmune reaction, and environmental factors and so on. Studies show that non-HLA gene, celluIar immunity, and nonspecific immune reaction etc. are relevant to LADA. Thorough research on the pathogenesis of LADA is helpful for understanding it＇s clinical characteristics, early prevention and diagnosis, proper treatment, and even exploring new therapeutic methods.
出处
《上海交通大学学报（医学版）》
CAS
CSCD
北大核心
2014年第4期546-550,共5页
Journal of Shanghai Jiao tong University:Medical Science
关键词
迟发型自身免疫性糖尿病
易感基因
体液免疫
细胞免疫
环境因素
latent autoimmune diabetes in adults
susceptibility gene
humoral immunity
cellular immunity
environmental factors
作者简介
鲁郡（1981-），男，博士生；电子信箱：lujundoctor@163．com。
贾伟平，电子信箱：WPjia@sjtu．edu．ca。
