摘要
炎症性肠病是一类病因不明的胃肠道慢性非特异性炎症,其发病过程是包括多种细胞因子在内的自身免疫的异常,最终导致组织的损伤,属于自身免疫性疾病的一种,其中肠道免疫系统调节异常在其发病机制中起着极其重要的作用,而作为重要的促炎因子和免疫调节因子肿瘤坏死因子α(TNF-α)、白细胞介素6(IL-6)在炎症性肠病的发病过程中参与炎症的发生以及信号的转导。该文就近年来TNF-α、IL-6在炎症性肠病发病机制中的研究予以综述。
Inflammatory bowel disease is a kind of unknown etiology of chronic nonspeeific inflammation of the gastrointestinal tract, the onset process of which includes a variety of cytokines immune abnormalities, eventually leading to the tissue damage;it is a kind of autoimmune disease,and the intestinal immune system dysregulation plays an extremely important role in the pathogenesis; tumor necrosis factor alpha and interleu- kin-6, as proinflammatory factors and immune adjustment factors are involved in inflammation and signal transduction in the pathogenesis of inflammatory bowel disease. Here is to make a review of the tumor necrosis factor alpha and interleukin-6 role in the pathogenesis of inflammatory bowel diseases.
出处
《医学综述》
2014年第7期1174-1176,共3页
Medical Recapitulate
关键词
肿瘤坏死因子Α
白细胞介素6
炎性肠病
Tumor necrosis factor alpha
Interleukin-6
Inflammatory bowel diseases
