摘要
目的：探讨年龄≤35岁年轻宫颈癌患者发病的临床病理特点。方法检索 Pubmed、Ovid-medline全文数据库、CNKI、维普数据库、万方数据库等并收集有关年龄≤35岁年轻宫颈癌患者与＞35岁的中老年宫颈癌患者的病例对照研究文献，按预定标准进行筛选，对纳入研究进行质量评价，并提取相应指标完成Meta分析。结果根据本研究的纳入与排除标准，最终纳入文献16篇，其中英文文献3篇，中文文献13篇，共包括13714例宫颈癌患者（年轻宫颈癌患者2582例，中老年宫颈癌患者11132例）。Meta分析表明：年轻宫颈癌患者临床分期为早期（0～ⅡA）发生率、病理组织学分型为宫颈非鳞癌（腺癌为主）发生率、组织学分级为低分化（G3）、盆腔淋巴结转移阳性发生率显著高于中老年宫颈癌患者。癌灶直径大于4 cm、宫颈基层浸润深度≥1/2、脉管浸润的差异无统计学意义。结论35岁以下年轻宫颈癌患者临床分期以早期癌为主，病理组织学分型为低分化非鳞癌，但生存率较中老年组低。应加强宫颈癌防治知识的宣传和筛查的推广，做到早诊断、早治疗。
Objective To investigate the young cervical cancer patients. Methods To retrieve Pubmed, Ovid medline, CNKI full-text database, VIP database, and collect relevant case-control study of literature about aged 35 years or younger and aged over 35 years patients with cervical cancer, according to predetermined standards. Then, we evaluated the quality of included studies, and extracted the corresponding indicators to complete the Meta analysis. Results According to the inclusion and exclusion standards of this study, eventually 16 references were included, of which 3 references in English and 13 references in Chinese, including a total of 13 714 patients with cervical cancer. There were 2 582 cases aged 35 years or younger and 11 132 cases aged over 35 years of cervical cancer patients. The Meta analysis showed that incidence of early FIGO stage（0-ⅡA）, pathological type for cervical non-squamous cell carcinomas（adenocarcinoma）, histologic classification of low differentiation（G3）, and pelvic lymph node metastasis positive incidence in young patients with cervical cancer was significantly higher than that elder patients with cervical cancer. There was no statistically significant difference in tumor diameter greater than 4 cm, depth of stromal invasion（DSI）, and lymph vascular space. Conclusion Patients aged 35 years or younger had a higher proportion of being in the early FIGO stage, pathological type for cervical non-squamous cell carcinomas, histologic classification of low differentiation（G3）. but with low survival rate.We therefore re-emphasize the importance of health education and regular smear screening so as to do early diagnosis and early treatment.
出处
《中华临床医师杂志（电子版）》
CAS
2014年第2期64-69,共6页
Chinese Journal of Clinicians(Electronic Edition)
关键词
女(雌)性
宫颈肿瘤
META分析
临床特征
Female
Uterine cervical neoplasms
Meta-analysis
Clinical characteristics
作者简介
通讯作者：魏芳，Email：2yuanweifang@163．com
