摘要
目的:建立用壳聚糖提高小儿解表止咳口服液澄明度的方法。方法:采用壳聚糖的絮凝作用对小儿解表止咳口服液进行处理。采用单因素试验和正交试验考察壳聚糖用量、澄清温度、澄清时间对有效成分盐酸麻黄碱质量浓度的影响,并与传统的醇沉法相比较。结果:最佳澄清工艺为1%壳聚糖溶液用量为15%,澄清温度为80℃,澄清时间为24 h;用壳聚糖絮凝法处理的小儿解表止咳口服液澄明度优于醇沉法,但提取的盐酸麻黄碱的质量浓度无明显差异。结论:壳聚糖絮凝法准确、简便、重现性好、成本低廉,可明显改善小儿解表止咳口服液的澄明度。
OBJECTIVE： To establish a method of improving the clarity of JBZK oral liquid by using chitosan. METHODS： JBZK oral liquid was treated with flocculation effect of chitosan. Single factor test and orthogonal experiment were adopted to inves- tigate the effects of different amount of chitosan, clarification temperature and clarification time on the concentration of ephedrine hydrochloride, and then compared with the water extraction and alcohol precipitation method. RESULTS： The optimal flocculation technology was as follows： 15% dose of 1% chitosan, clarification temperature at 80 ℃ and clarification time of 24 h. The clarity of the JBZK oral liquid treated by chitosan flocculence method was better than treated by alcohol precipitation method. The contents of ephedrine hydrochloride had no significant difference between 2 methods. CONCLUSIONS： The chitosan flocculence method is accurate, simple, reproducible and cheap, and can improve the clarity of JBZK oral liquid.
出处
《中国药房》
CAS
CSCD
2014年第15期1389-1391,共3页
China Pharmacy
作者简介
副教授。研究方向：中药及天然药物的成分和质量。电话：028-85193189。E—mail：824380313@qq．com
