摘要
目的观察糖尿病患者应用角膜缘干细胞移植联合适宜浓度丝裂霉素C治疗翼状胬肉的临床疗效。方法临床病例系列研究。对于2007年9月至2012年12月在内蒙古民族大学附属医院眼科就诊的患有Ⅱ型糖尿病的63例翼状胬肉患者（79只眼）行自体角膜缘干细胞移植联合0．1mg／ml丝裂霉素C治疗，随访6～48个月，观察术前、术后视力与屈光状态的变化情况，以及角膜修复、植片愈合和复发情况。结果Prabhasawat分级：1级愈合的58只眼占73．42％，2级11只眼占13．92％，3级8只眼占10．13％，4级2只眼占2．53％。术后患者裸眼视力均有不同程度提高，散光度数均较术前明显下降，差异有统计学意义（P〈0．05）。植片全部成活，无明显并发症发生。结论自体角膜缘干细胞移植联合适宜浓度的丝裂霉素C是治疗糖尿病患者翼状胬肉的理想术式。
Objective To investigate the clinical outcome of limbal stem cells transplantation combined with mitomycin C treatment of pterygium in diabetic patients. Methods Sixty-three cases （79 eyes） with diabetic pterygium were treated with autologous limbal stem cell conjuctiva limbal transplantation and mitomycin C at 0.1mg/ml. The diabetics should be followed up for 6-48 months and then preoperative status, postoperative vision, the changes of refractive state and the cases of cor- nea repair, implant healing and recurrence were observed. Results Based on four levels of Prabha- sawat classification, Level one healing was 58 eyes （73.42%）, Level two healing 11 eyes （13.92%）, Level three healing 8 eyes （10.13%）, and Level four healing 2 eyes （2.53%）. The postoperative naked vision of all patients had different degree of improvement and astigmatism degree declined obviously than preoperative, there was statistic significant （P 〈0.05）. All grafts survived and no obvious complica- tions occurred. Conclusions The autologous limbal stem cells transplantation combined with appropri- ate concentration mitomycin C is the ideal operation for treatment of pterygium patients with diabetes.
出处
《中国实用眼科杂志》
CSCD
北大核心
2014年第3期286-288,共3页
Chinese Journal of Practical Ophthalmology
关键词
糖尿病
角膜缘干细胞
丝裂霉素C
移植
Diabetic
Limbus cornea stem cells
Mitomycin C
Transplantation
作者简介
通信作者：韩立坤，Email：ztzhlk6646@126.com
