摘要
目的：采用Meta分析方法系统评价高尔基体糖蛋白73（golgiprotein-73，GP73）在原发性肝癌诊断中的价值。方法：查找PubMed、EMbase和PML等多个数据库，检索建库至2012—12—31GP73诊断原发性肝癌价值的相关文献。应用Meta—Disc1．4软件对纳入文献进行综合定量评价，并绘制受试者工作特征曲线（summaryreceiveroperatingchar—acteristiccurve，SR0c），对GP73诊断肝癌的准确性进行评估。结果：共纳入18篇文献，敏感度（sensitivity，SEN）合并为0．76，95％CI：0．75～0．78；特异度（specificity，SPE）合并为0．87，95％CI：0．86～0．88；诊断比值比（diagnosticoddsratio，DOR）为16．71，95％CI：8．54～32．74；SROC曲线下面积0．858。GP73对原发性肝癌有较好的辅助诊断价值。亚组分析结果显示，ELISA检测方法的阳性似然比（positivelikelihoodratio，PLR）合并、DOR合并和曲线下面积（areaundercurve，AUC）都高于蛋白质印迹方法，其余各效应量基本相同，ELISA法检测效能优于蛋白质印迹法。纳入文献存在异质性，主要来源为研究地区差异及研究对象肝病背景不同。描绘Begg漏斗图并进行Begg秩相关检验，提示无明显发表偏倚，P=0．130。结论：GP73诊断原发性肝癌具有较高的SEN和SPE，但存在异质性，还需要更高质量的前瞻性研究以更准确的评价其临床价值。
OBJECTIVE： To observe the diagnostic value of golgiprotein-73 （GP73） in patients with primary liver cancer by a Meta-analysis. METHODS： Such databases as PubMed, EMbase, PML and others were searched. Qualified studies of GP73 in diagnosis of liver cancer in English and Chinese published were collected. Statistical analyses were per- formed by software Meta-Disc 1.4 vision,and summary receive operating characteristic （SROC） curve was performed. RE- SULTS： Eighteen of retrieved articles were included. The included studies had heterogeneity. The pool SEN and SPE for GP73 and 95% confidence interval （95%CI） was 0.76 [95%CI（0.75,0.78）] and 0.87 [-95%CI（0.86,0.88）],respective- ly. The pool DOR was 16.71 [95%CI（8.54,32.74）] ,the AUC of SROC was 0. 858,Showed a great auxiliary diagnostic value of GP73. From the subgroup analysis, the PLR combined, DOR combined and AUC of ELISA technology were better than Western Blotting method while other effects were similar,indicated ELISA had higher efficiency of diagnosis. There was heterogeneity in the included studies. The difference of areas and disease background of study objects were the main sources. Begg funnel plot suggested the publication bias was not significant （Begg＇s test P= 0. 130）. CONCLUSIONS： Meta-analysis indicates that GP73 is a valuable diagnostic method which has higher sensitivity and specificity in detecting liver cancer. But the study has heterogeneity, more supports from high quality prospective researches are desired.
出处
《中华肿瘤防治杂志》
CAS
北大核心
2014年第5期387-392,共6页
Chinese Journal of Cancer Prevention and Treatment
基金
广西自然科学基金(0832235)
广西科技攻关项目(0816004-13
1140003A-32)
广西医疗卫生重点科研课题(重2011085)
作者简介
【第一作者简介】梁嵘，女，广西柳州人，博士，主治医师，主要从事肿瘤标志的研究工作。，Tel：86—771—5333058E—mail：leona811@foxmail．com.
【通讯作者简介】罗小玲，女，广西陆川人，博士，教授，主任技师，主要从事肿瘤免疫与生物治疗的研究工作。Tel：86—771—5358959E-mail：luoxiaoling001@163．com.
