摘要
目的研究氯吡格雷、阿托伐他丁对不稳定型心绞痛患者IL-6、hs-CR及预后的影响。方法将130例不稳定型心绞痛患者随机分为常规治疗的对照组和在常规治疗基础上给予氯吡格雷、阿托伐他丁治疗的观察组,每组各65例,检测治疗前后IL-6、hs-CR水平及血液流变学指标。结果观察组患者的IL-6(0.429±0.094)ng/L、hs-CRP(5.61±0.97)ng/L水平以及红细胞聚集指数(1.4±0.3)、毛细血管血浆黏度(0.9±0.2)mPa·s、低切全血黏度(9.5±1.9)mPa·s、中切全血黏度(5.8±1.1)mPa.s、高切全血黏度(5.4±1.1)mPa·s均明显低于对照组(均P<0.05)。结论氯吡格雷、阿托伐他丁治疗能够降低IL-6、hs-CR水平,改善血流动力学状况,对于不稳定型心绞痛的治疗具有积极意义。
Objective To study the effect of clopidogrel and atorvastatin on IL-6, hs-CR and prognosis of unstable angina patients. Methods Unstable angina patients were randomly divided into control group given conventional treat- ment and observation group given clopidogrel and atorvastatin. IL-6, hs-CR level and hemorheology indexes were detec- ted. Results IL-6（0. 429±0. 094）ng/L, hs-CRP （5.61±0.97）ng/L levels and erythrocyte aggregation index（1.4± 0.3）, blood capillary plasma viscosity（0. 9 ±0.2） mPa. s, low shear whole blood viscosity（9.5±1.9） mPa. s, middle shear whole blood viscosity（5.8 ±1.1）mPa. s, high shear whole blood viscosity（5.4 ± 1.1）mPa. s of observation group were lower than that of control group. Conclusion Clopidogrel and atorvastatin have positive value to unstable angina pa- tients for it can reduce IL-6 and hs-CR level and improve the hemodynamic status.
出处
《西部医学》
2014年第3期325-327,共3页
Medical Journal of West China
