摘要
[目的]研究芦竹碱的微波辅助合成方法。[方法]以吲哚和二甲胺、甲醛为原料,使用乙酸作为催化剂,以微波辅助方法合成芦竹碱,考察了催化剂、溶剂、温度、反应时间、原料摩尔比对产率的影响。[结果]产率最高达到98.1%,产物通过红外、核磁进行表征。[结论]微波辅助法合成芦竹碱操作简便、收率高、用时短、符合绿色化学的要求。
[Aims] A new method of microwave （MW） assisted synthesis of gramine was developed. [Methods} Gramine was synthesized using indole, dimethylamine, and formaldehyde as starting materials, and acetic acid as catalyst. The effects of the reaction temperature, reaction time, solvent, solvent volume and the molar ratio on yields were studied, and the optimal conditions of microwave assisted synthesis of gramine salt were determined. [Results] The products were characterized by 1H NMR and IR with yields up to 98.1%. [Conclusions] Synthesis of gramine under microwave irradiation reactions has such advantages of simple operation, high yields and short reaction time, which complies with the requirements of green chemistry.
出处
《农药》
CAS
CSCD
北大核心
2014年第3期176-178,共3页
Agrochemicals
基金
贵州师范大学博士科研启动费(05032130020)
贵州师范大学2013校级大学生创新创业计划
关键词
芦竹碱
微波
曼尼希反应
gramine
microwave irradiation
Mannich reaction
作者简介
作者简介：尹晓刚（1976-），男，副教授，研究方向为有机合成及材料化学。Tel：0851—6700050，E-mail：m13885115516@163．com。
