摘要
目的观察国产特利加压素治疗肝硬化并发肝肾综合征(HRS-Ⅱ)的疗效。方法选取2006—2011年就诊本院HRS患者52例,分成2组,对照组27例,治疗组25例。在内科综合治疗基础上,分别使用多巴胺、速尿和特利加压素。治疗期间观察两组患者血肌酐、尿素氮、尿量、肝功能以及电解质等指标变化。结果治疗结束后治疗组临床症状有明显改善,尿量由治疗前(683.3±225.2)ml增加到(1654.5±404.9)ml,血尿素氮由(18.9±2.4)mmoL/l降到(18.9±2.4)mmol/L,血清肌酐由(185.2±45.7)μmol/L降到(138.8±38.7)μmol/L,这三项指标与治疗前比较,差异均有统计学意义(P<0.05)。治疗组与对照组比较,上述三项指标改变更明显,差异均有统计学意义(P<0.05),治疗组无其他严重不良事件发生。结论在内科综合治疗的基础上,国产特利加压素治疗肝硬化并发肝肾综合征(HRS-Ⅱ)有较好疗效,不良反应小。
Objective To investigate the curative effect of domestic terlipressin in the trentment of decompensated cir- rhotic patients with hepatorenal syndrome （HRS - 11 ）. Methods 52 patients with hepatorenal syndrome in our hospital from Jan 2006 to Dec 2011 were divided into treatment group and control grop. The teeatment group was treated with terlipressin, The control group was treated with dopamine and furosemide, based on comprehensive medical treatmemt. The clinical symptoms, urine output, serum ereatinine level, blood urea nitrogen, ascites and outcome of the two groups were observed. Results In the treatment group, the clinical symptoms improved significantly, the total urine output increased from （483. 3 ±225.2） ml to （ 1654. 5 ±404.9） ml, blood urea nitrogen decreased from （ 18.9 ± 2. 4） mmol/L to （ 18. 9 ± 2. 4） mmol/L, and serum ere- atinine decreased from （ 185.2±45.7） μmol/L to （ 138. 8±38.7 ） μmol/L. Compared with the pretherapy levels, the levels of the three markers were significantly different （ P 〈 0. 05 ）. There was significant difference in the post - therapy levels of the three markers between terlipressin group and dopamine group （ P 〈 0. 05 ）. There is no other serious adverse events occured in two groups. Conclusion Based on the comprehensive medieal treatment, domestic terlipressin Shows good efficacy and few ad- verse reactions in the treatment of decompensated cirrhotic patients with hepatorenal syndrome （ HRS - II ）, and it is affordable in economy and worth of clinical applicalion..
出处
《临床合理用药杂志》
2014年第6期27-29,共3页
Chinese Journal of Clinical Rational Drug Use
关键词
肝硬化
肝肾综合征
治疗结果
Liver cirrhotic
Hepatorenal syndrome
Treatment outcome
