摘要
目的 对康艾注射液辅助治疗鼻咽癌的临床疗效、毒副作用和药物经济学进行评价.方法 对来自北京军区总医院采用康艾注射液辅助治疗的鼻咽癌患者进行回顾性队列研究.结果 符合研究条件的鼻咽癌患者共217例,其中121例合并使用康艾注射液治疗（康艾组）,男91例,女30例,年龄22～71岁,平均（47.0±11.8）岁；96例未使用康艾注射液（非康艾组）,男69例,女27例,年龄25～75岁,平均（45.2±11.2）岁,两组基线差异无统计学意义.治疗后,康艾组瘤体缩小的有效率为32.2％,与非康艾组（38.5％）比较,差异无统计学意义（P=0.333）；两组治疗后白细胞计数均明显下降,但治疗后康艾组与非康艾组差异无统计学意义（P=0.598）.康艾组放化疗后呕吐、头晕、精神不佳发生率分别为19.0％、2.5％和9.1％,明显低于非康艾组的34.4％、11.5％和18.8％.康艾组药品费用较高,但两组住院总费用差异无统计学意义（P=0.703）；考虑社会劳动成本,两组总成本相比差异无统计学意义（P=0.689）.康艾组能减轻治疗呕吐、头晕和精神不佳症状,成本-效果更优.结论 康艾注射液对鼻咽癌化疗引起的毒副反应有一定的改善效果.
Objective To evaluate the effectiveness and pharmacoeconomics of Kangai injection as the adjuvant treatment on nasopharyngeal carcinoma. Methods A retrospective cohort study was employed ine]uding 217 cases with nasophaITngeal carcinoma in the General Hospital of Beijiug Command of PLA. Among them, 121 eases were treated with combined Kangai injection （91 male, 30 female）. The ages ranged fl＇om 22 to 71 with the average age of （ 47.0±11.8 ） years oht. Ninety-six cases were not treated with Kangai injection （69 male, 27 female）. The age ranged from 25 to 75 years old with the average of （ 45.2±11.2 ） years old. Results According to the iuelusion criteria, 217 patients suffered from nasopharyngeal carcinoma. They were divided into the Kangai group while others were in the non-Kangai group. No significant difference between the two groups in these baseline information was found. After treatment, the efficiency of tmnor size reduction in the two groups was 32.2% and 38.5% respectively, and the difference was not significant （P = 0.333）. Leukocytes were significantly decreased by treatment in both of the two groups, however, no significant difference was found. The incidence of wmliting, dizziness, poor spirit were 19.0%, 2.5% and 9.1% respectively in the Kangai group, which were significantly lower than those of the non-Kangai group （34.4%, 11.5%, 18.8% respectively）. Drug cost was higher in the Kangai group, but no significant difference between the two groups in the total cost of hospitalization （P = 0.703）. Considering the social cost of labor, total costs of the two groups had no statistical significance （P = 0.689）. Kangai could reduce vomiting, dizziness and depression induced by radiotherapy, chemotherapy, and its cost-effectiveness was better. Conclusion Kangai injection has certain improvement about adverse reaction caused by chemotherapy in nasopharyngeal carcinoma.
出处
《北京医学》
CAS
2014年第2期118-121,共4页
Beijing Medical Journal
关键词
康艾注射液
鼻咽癌
疗效
毒副作用
成本-效果比
Kangai injection Nasopharyngeal carcinoma Therapeutic effects Side effects Cost-effective- ness ratio
作者简介
通信作者：王勇．E-mail：yongwh2005@163．com
