摘要
目的：分析免疫增强型肠内营养同步干预对胃肠道肿瘤患者术后炎症反应和预后的影响。方法选取义乌市中心医院2009年10月-2012年11月消化道恶性肿瘤手术患者50例，按分层随机分组法分为观察组与对照组各25例，观察组给予免疫增强型肠内营养同步干预，对照组给予常规肠内营养干预，手术前后对外周血血清蛋白指标包括总蛋白、白蛋白、前白蛋白、转铁蛋白浓度，免疫指标如IgG、IgM、IgA和淋巴细胞总数，以及炎症指标IL-6和CRP浓度进行检测，同时记录患者的并发症情况。结果术后5 d和9 d观察组的白蛋白含量分别为（36．03±177;6．59），（39．46±177;6．01）g/L，分别高于对照组的（29．45±177;4．47），（30．35±177;6．34）g/L，差异有统计学意义（t值分别为4．132，5．214；P＜0．01）；术后9 d观察组转铁蛋白为（3．55±177;1．07）g/L，高于对照组的（2．96±177;0．97）g/L，差异有统计学意义（t＝2．043， P＜0．05）；术后9 d观察组IgG和IgA分别为（15．59±177;4．14），（4．53±177;2．13） g/L，分别高于对照组的（11．96±177;2．49），（2．68±177;1．05）g/L，差异有统计学意义（t值分别为3．757，3．895；P＜0．01），IL-6和CRP浓度分别为（135．38±177;33．02）pg/ml，（7．78±177;3．53）mg/L，低于对照组，差异有统计学意义（P＜0．01）；观察组并发症发生例数为7例，低于对照组的14例，差异有统计学意义（χ2＝4．023，P＜0．05）。结论免疫增强型肠内营养能减轻胃肠道肿瘤外科术后创伤应急产生的炎症反应，加快白蛋白和转铁蛋白合成，促进肠功能的恢复，改善患者预后，是临床更适合给予的肠内营养。
Objective To analyze the effect of immune-enhancing enteral diets （ IEDs ） synchronous＆amp;nbsp;intervention on inflammatory response and prognosis of patients with gastrointestinal cancer after operation . Methods Fifty patients with gastrointestinal malignant tumor after operation from October 2009 to November 2012 were divided into the observation group and control group according to the stratified random grouping , each with 25 cases.The observation group received the IEDs synchronous intervention , and the control group received the routine enteral diets intervention .The indicators of blood serum protein including total protein , albumin, prealbumin, ferritin, indicators of immune such as IgG , IgM, IgA, and total lymphocyte count , and markers of inflammatory such as IL-6 and CRP were detected , and the complications of patients were recorded before and after the operation.Results The content of albumin in the observation group was respectively （36.03 ±177;6.59）, （39.46 ±177;6.01）g/L on the fifth and ninth day after the operation, which was higher than （29.45 ±177;4.47）, （30.35 ±177;6.34）g/L in the control group, and the differences were statistically significant （t=4.132, 5.214, respectively;P＆lt;0.01）.The content of transferring in the observation group was （3.55 ±177;1.07） g/L on the ninth day after the operation, which was higher than （2.96 ±177;0.97）g/L in the control group, and the difference was statistically significant （t=2.043, P＆lt;0.05）.The IgG and IgA in the observation group was respectively （15.59 ±177;4.14）, （4.53 ±177;2.13）g/L on the ninth day after the operation, which was higher than （11.96 ±177; 2.49）, （2.68 ±177;1.05）g/L in the control group, and the differences were statistically significant （t=3.757, 3.895,respectively;P＆lt;0.01）.The concentration of IL-6 and CRP in the observation group was respectively （135.38 ±177;33.02）pg/ml, （7.78 ±177;3.53）mg/L on the ninth day after the operation, which was lower than that in the control group, and the differences were statistically significant （P＆lt;0.01）.The cases of complication in the observation group were 7 cases, which were lower than 14 cases in the control group , and the difference was statistically significant （χ2 =4.023, P＆lt;0.05）.Conclusions IEDs can significantly reduce the inflammatory reaction induced by trauma in the patients with gastrointestinal cancer after operation , accelerate the synthesis of albumin and transferring , promote the recovery of intestinal function , improve the prognosis of patients .
出处
《中华现代护理杂志》
2014年第1期62-65,共4页
Chinese Journal of Modern Nursing
关键词
预后
免疫增强型肠内营养
胃肠道肿瘤
炎症反应
Prognosis
Immune-enhancing enteral diets
Gastrointestinal cancer
Inflammatory reaction
作者简介
通信作者：傅亚玲，Email：403486380@qq．com
