摘要
目的探讨卡维地洛治疗高血压合并糖尿病患者的心律失常的临床疗效及安全性。方法选择2011年10月至2013年10月在河北医科大学附属哈励逊国际和平医院住院治疗的高血压合并糖尿病心律失常患者,随机分为试验组和对照组。对照组患者给予降糖、血管紧张素转换酶抑制剂降压等常规治疗,试验组在对照组用药基础上加用卡维地洛。观察、记录并分析两组患者治疗后的疗效和不良反应。结果共纳入140例患者,试验组和对照组各70例,对照组有10例失访,故最终试验组70例、对照组60例纳入分析。结果显示:试验组总有效率(χ2=8.320,P=0.004)和室性期前收缩的动态心电图改善情况(χ2=5.333,P=0.014)优于对照组,其差异均有统计学意义。两组患者治疗后血压和心率较治疗前均明显改善,且治疗后试验组与对照组血压和心率差异有统计学意义(P均<0.05),试验组更优。治疗过程中,试验组有3例出现消化道症状,但其症状轻微,均能自行缓解。结论卡维地洛治疗高血压合并糖尿病心律失常患者的临床治疗效果显著,安全有效,值得临床应用。
Objective To investigate the clinical efficacy and safety of carvedilol in the treatment of arrhythmia in patients with hypertension complicated with diabetes mellitus. Methods We selected the patients with hypertension complicated with diabetes mellitus who were hospitalized in the Harrison International Peace Hospital Affiliated to Hebei Medical University for treatment from Oct. 2011 to Oct. 2013. The cases were divided into a trial group and a control group. The control group was given routine treatment （eg., hypoglycaemic drugs, angiotensin converting enzyme inhibitors）. On the basis of the same treatment of the control group, the trial group was given carvedilol. The efficacy and adverse reaction were observed, recorded and then analyzed between the two groups. Results A total of 140 patients were included （70 cases in each group）. With the loss of 10 cases in the control group, the data of 70 cases in the trial group and 60 cases in the control group were finally analyzed, The results showed that the trial group was superior to the control group in the total effectiveness （χ2=8.320, P=0.004） and the dynamic ECG improvement of premature ventricular contraction （χ2=5.333, P=0.014） with significant differences. Both groups were significantly improved in blood pressure and heart beats compared with the situation before treatment （Both P〈0.05）, and the trial group was better than the control group with a significant difference. During the treatment, three cases in the trial group had mild gastrointestinal symptoms which spontaneously disappeared later. Conclusion The clinical effectiveness of carvedilol for arrhythmia in patients with hypertension complicated with diabetes mellitus is significant. It is safe and effective which is recommended in clinical application.
出处
《中国循证医学杂志》
CSCD
2014年第2期152-155,共4页
Chinese Journal of Evidence-based Medicine
关键词
卡维地洛
高血压
糖尿病
心律失常
随机对照试验
Carvedilol
Hypertension
Diabetes Mellitus
Arrhythmia
Randomized controlled trial
作者简介
李敬，女（1978年～），硕士，主治医师，以心血管疾病为主要研究方向。Email：zhiyeyishi007@sina．com．cn
