摘要
目的:脑白质病变与老年认知功能障碍关系密切,尤其是深部白质病变更是血管性认知功能损害的常见危险因素,但临床上对于侧脑室旁白质病变与认知功能损害的关系研究较少,本研究旨在探讨侧脑室旁白质病变患者认知功能损害的特点。方法:选取2011年2月-2012年10月住院健康查体者159例,根据有无侧脑室旁白质病变分为脑白质病变组及对照组,根据侧脑室白质病变严重程度分为轻度组及中重度组。所有患者分别进行蒙特利尔认知评估表(Montreal Cognitive Assessment,MoCA)中文版、简易精神状态检查表(Mini Mental State Examination,MMSE)和画钟测验(clock drawing test,CDT)评估。结果:脑白质病变组MMSE量表总分、CDT、MoCA量表总分及视空间、计算力、延迟回忆及空间执行功能分低于对照组,差异有统计学意义(P<0.05);白质病变中重度组MMSE、MoCA量表总分及计算力得分低于轻度组,差异有统计学意义(P<0.05)。结论:本研究显示侧脑室旁白质病变患者总体认知功能评分明显低于对照组,中重度患者的计算力下降尤为突出,提示我们侧脑室旁白质病变是导致患者总体认知功能下降及计算力损害的危险因素,临床上应该提高对于侧脑室旁白质病变的重视。
Objective： To study the character of cognitive impairment in patients with peri-ventricular hyperintensity （PVH）. Methods： 159 people who were admitted for health screen were divided into white matter lesions group and control. Furthermore they were divided into mild group and mediate to severe group according to the PVH score. Montreal Cognitive Assessment （MoCA）, Mini Mental State Examination （MMSE）and clock drawing test （CDT） were taken to all subjects. Results： The score of MMSE, MoCA and CDT of white matter lesions group were significantly lower than control, as well as the sub item score of MoCA including Visuospatial skill, calculation, delay recall and orientation （P〈0.05）. The score of MMSE, MoCA and calculation of mediate severe group were significantly lower than mild group（P〈0.05 ）. Conclusion： Peri-ventricular hyperintensity was associated with general cognitive impairm- ent and calculation decline.
出处
《现代生物医学进展》
CAS
2014年第1期104-107,共4页
Progress in Modern Biomedicine
关键词
脑白质病变
认知功能
神经心理
White matter lesions
Cognition
Neuropsychology
作者简介
作者简介：王炜（1972一），女，心理学博士，副主任医师，老年神经病学，电话：010—66876347，E—mail：wangwei301@hotmail．com
