摘要
目的 探讨血清同型半胱氨酸水平对急性冠脉综合征的临床意义.方法 选择佛山市南海区第六人民医院急诊科2010年6月～2012年6月收治的146例急性冠脉综合征（ACS）患者,分为不稳定性心绞痛（UA）组（85例）以及急性心肌梗死（AMI）组（61例）;依据冠脉数量将107例分为一支组（29例）、二支组（37例）、三支及三支以上组（41例）.对患者的血清Hcy水平进行测定,并选择60例健康体检者作为对照组.结果 UA组和AMI组患者血清Hcy水平分别为（16.12±5.49）、（21.01±6.52） μmol/L,高于对照组的（10.89±3.91） μmol/,差异有统计学意义（P＜ 0.05）;AMI组患者血清Hcy水平高于UA组,差异有统计学意义（P＜0.05）.冠脉一支组、二支组和三支及三支以上组患者Hcy水平分别为（13.18±4.92）、（16.04±3.21）、（21.86±4.93） μ,mol/L,组间比较差异有统计学意义（F=19.251,P=0.003）,其中二支组和三支及三支以上组高于一支组,三支及三支以上组高于二支组,且均高于对照组,差异均有统计学意义（P＜0.05）.结论 ACS患者的Hcy水平高于正常人群,且和患者冠脉的支数有关,在临床上可以通过检测患者的Hcy水平来对ACS进行预防和治疗.
Objective To discuss clinical significance of measurement of serum homocysteine level in patients with a cute coronary syndrome. Methods 146 ACS patients from June 2010 to June 2012 in the Sixth People＇s Hospital of Naihai District in Foshan City were selected. They were divided into unstable angina （UA） group with 85 cases and a cute myocardial infarction （AMI） group with 61 cases. According to the number of affected coronary branches verified, 107 patients were divided into one branch group （29 cases）, two branches group （37 cases）, three and more than three branches group （41 cases）. 60 healthy individuals were chosen as control group. Level of serum Hcy was measured in all groups. Results Level of serum Hcy in UA group [（16.12 ±0.49） μmol/L] and AMI group [（21.01±.52） μmol/L] were higher than that in control control [（10.89±.91） μmol/L], the differences were statistically significant （P 〈 0.05）; the differences of serum Hcy between UA group and AMI group was statistically significant （P 〈 0.05）. The differences of levels of serum Hcy in one branch group [（13.18±.92） μmol/L], two branches group [（16.04±.21） μmol/L] and three and more than three branches group [（21.86±.93） μmol/L] were statistically significant （F = 19.251, P 〈 0.05）; the levels of serum Hey in two branches group and three and more than three branches group were higher than those in one branch group, the levels of serum Hcy in three and more than three branches group was higher than that in two branches group, the differences were statistically significant （P 〈 0.05）; the levels of serum Hcy in three groups was higher than that in control group, the differences were statistically significant （P 〈 0.05）. Conclusion The level of serum Hey in ACS patients is significantly higher than that in normal people, and it is related to the number of coro- nary artery. The measurement of serum Hcy level can play an important role in the prevention, treatment and monitor- ing for ACS.
出处
《中国医药导报》
CAS
2014年第5期64-66,共3页
China Medical Herald
基金
广东省佛山市医学类科技攻关项目(编号2010 08150)
