摘要
用计算机检索中国知网、万方数据库和PubMed中近10年相关文献,检索词分别为"中药、骨髓间充质干细胞、神经样细胞、分化"和"Traditional Chinese medicine,Bone Marrow Mesenchymal Stem Cells,neural cells,differentiation",检索式分别为"并"和"and"。共检索到中文文献630篇,英文文献363篇,根据文献筛选标准剔除重复及不规范的文献,共纳入39篇文献。发现中药诱导骨髓间充质干细胞(MSCs)向神经样细胞分化的研究以中药复方制剂、单味中药、中药有效成分或部位的内容为多,这表明目前此方面研究为热点。中药有效成分或部位作用机制的解释更符合现代医学药理理论,而且更易结合并体现现代实验方法和技术的运用。用现代医学药理实验方法与技术研究中药诱导MSCs向神经元样细胞分化的同时,应当深化并体现传统中医药学药性法则、中药炮制方法、辨证论治理论等特色。为用中药作为诱导剂来防治缺血性脑疾病等神经系统疾病提供了一定理论依据。
To summarize the differentiation research progress of traditional Chinese medicine （TCM） inducing bone marrow mesenchymal stem cells to neural cells. First author searched the literatures from CNKI database, Articles Database and PubMed database of the last 10 years. The key words were ＇ Traditional Chinese Medicine, Bone Marrow Mesenchymal Stem Cells, neural cells, differentiation＇ in Chinese and English. The retrieval type was and in Chinese and English. A total of 630 articles in Chinese, 363 articles in English were obtained and 39 articles were included accoding to the literature selection criteria, removed repeated and non- standard articles. Among the researches of TCM inducing bone marrow mesenehymal stem cells to neural cells differentiation, most are the researches of compound preparations, the single taste and effective compounds or parts of TCM, and provide a certain theoretical basis for TCM that used as an inducer of preventing and treating nervous system diseases, such as ischemic cerebral disease.
出处
《中国实验方剂学杂志》
CAS
北大核心
2014年第3期219-224,共6页
Chinese Journal of Experimental Traditional Medical Formulae
基金
国家自然科学基金项目(81260569)
关键词
中药
骨髓间充质干细胞
神经样细胞
分化
traditional Chinese medicine
bone marrow mesenehymal stem cells
neural cells
differentiation
作者简介
虎喜成，在读研究生，攻读中医药防治老年病研究，Tel：13723383157，E-mail：925429601@qq．com
[通讯作者]刘敬霞，博士，副教授，副主任医师，硕士生导师，从事中医药防治老年病研究，Tel：13519216687，E-mail：ljx199566@163．com
