摘要
目的:分析新生儿败血症合并胆汁淤积症患儿的血清内毒素水平及临床意义。方法:46例诊断为败血症的新生儿,其中合并胆汁淤积者25例(胆汁淤积组),无胆汁淤积者21例(无胆汁淤积组),分别测定两组患儿治疗前和治疗后的血清内毒素水平,比较两组患儿之间血清内毒素水平差异。结果:胆汁淤积症患儿治疗前血清内毒素水平(36.83±10.12)pg/mL,明显高于无胆汁淤积组的(11.05±3.11)pg/mL(P<0.05),胆汁淤积组治疗好转后血清内毒素水平(14.32±6.21)pg/mL,明显低于治疗前的(36.83±10.12)pg/mL(P<0.05)。结论:内毒素是败血症新生儿出现胆汁淤积症的重要因素之一。
Objective： To analyze the level of serum endotoxin in neonates with septicemia combined with cholestasis and its clinical significance. Methods： Forty-six newborns with septicemia were divided into two groups according to the results of whether having cholestasis or not. The levels of serum endotoxin were detected before and after the treatment. Endotoxin levels in the two groups were compared. Results： The level of serum endotoxin in sepsis-associated cholestasis group was （36. 83±10. 12） pg/mL, which was significantly higher than that in the control group （11.05±3. 11） pg/mL （P〈0. 05）, and it was gradually decreased after treatment （14. 32±6. 21） pg/mL （P〈0. 05）. Conclusions： Endotoxin is one of the important factors to develop cholestasis in newborns with septicemia.
出处
《儿科药学杂志》
CAS
2014年第1期1-3,共3页
Journal of Pediatric Pharmacy
作者简介
刘靖（1983～），女，大学本科，主管护师，主要从事新生儿疾病护理工作，E—mail：13659806689@163．com。
