摘要
目的:对1,2-丙二醇样品中未知杂质进行质谱确证。方法:运用GC-MS法,采用AB-INOWAX毛细管柱(30 m×0.25 mm,0.25μm);柱温:起始温度60℃,保持3 min,以10℃·min^(-1)升温至220℃,保持4 min;EI源温度:230℃。结果:样品中未知杂质实为已知杂质一缩二丙二醇的异构体。结论:该方法简便、快速、灵敏度高,可用于1,2-丙二醇中有关物质的定性检测。
Objective：To establish a GC-MS method to identify the related unknown suhslances in propylene glycol.Method：A GC-MS method using an AB-INOWAX capillary column（30 m×0.25 mm,0.25 μm）with temperature programming was employed. The initial temperature was 60℃,kept for 3min,risen to 220℃ with a rate of 10℃ ？min-1,and kept for 4min.The temperature of ion source was 230℃.Result：The unknown substances in four samples were the isomerides of dipropylene glycol.Conclusion：The method is fast,simple and reproducible,and suitable for the identification of the related substances in propylene glycol.
出处
《中国药师》
CAS
2013年第12期1817-1819,共3页
China Pharmacist
作者简介
通讯作者：范硕Tel：13548954035E-mail：156658863@qq．com
