摘要
目的探讨腹腔镜术后联合3种不同药物治疗卵巢子宫内膜异位囊肿的疗效。方法回顾性分析本院2008年1月～2012年1月诊断为卵巢子宫内膜异位囊肿的患者共148例，均行腹腔镜下卵巢子宫内膜异位囊肿剥除术，术后随机分为4组：对照组40例，术后皮下注射促性腺激素释放激素类似物组（GnRH—α组）40例，术后口服孕三烯酮组（孕三烯酮组）38例，术后口服米非司酮组（米非司酮组）30例，对比4组患者术后临床症状缓解率、年复发率、妊娠率和不良反应发生率。结果GnRH—α组、孕三烯酮组、米非司酮组临床症状缓解率、年复发率、妊娠率与对照组比较，差异有统计学意义（P〈0．05）。GnRH—α组临床症状缓解率、年复发率、不良反应发生率分别与孕三烯酮组、米非司酮组比较，差异有统计学意义（P〈0．05），妊娠率差异无统计学意义（P〉0．05）。孕三烯酮组临床症状缓解率、年复发率、妊娠率和不良反应发生率与米非司酮组比较，差异无统计学意义（P〉0．05）。结论腹腔镜手术后联合GnRH-α、孕三烯酮或米非司酮治疗，对比单纯手术治疗可降低卵巢子宫内膜异位囊肿复发，提高妊娠率；孕三烯酮和米非司酮预防复发的效果及术后妊娠率无差异；GnRH—α不良反应最少，治疗有效率最高。
Objective To investigate the efficacy of laparoscope conservative surgery combined with different drugs in treatment of the ovarian endometriosis cyst.Methods 148 patients with ovarian endometriosis cyst undergoing laparo- scopic ovarian endometriosis cyst decortication in our hospital from Jan. 2008 to Jan. 2012 were enrolled in this restro- spective study.All the patients after the surgery were randomly divided into 4 groups：control group （40 cases）,mifepris- tone group （30 cases）,gestrinone group （38cases）,and GnRH-α group （40 cases）.The clinical remission rate,recurrence rate,pregnancy rate and the incidence of adverse reaction was compared between four groups.Results The clinical remission rate,recurrence rate,and pregnancy rate of mifepristone group,gestrinone group and GnRH-α group was sig- nificantly different from that of the control group （P〈0.05）.The clinical remission rate,recurrence rate,and the incidence of adverse reaction of GnRH-α group was significantly different from that of mifepristone group and gestrinone group （P〈0.05）,but the difference of the pregnancy rate showed no significant （P〉0.05）.The difference of clinical remission rate,recurrence rate,pregnancy rate and the incidence of adverse reaction between mifepristone group and gestrinone group showed no significant （P〉0.05）.Conclusion Compared to control group,the recurrence rate of ovarian endometriosis cyst of mifepristone group,gestrinone group and GnRH-α group after surgery can be significantly reduced,and the preg- nancy rate can be significantly raised.The recurrence rate and the pregnancy rate between mifepristone group and gestrinone group was not significantly different.The incidence of adverse reaction of the GnRH-α group was least and the clinical remission rate of it is highest.
出处
《中国当代医药》
2014年第1期59-61,共3页
China Modern Medicine
作者简介
罗雪芹（1976-），女，大学本科，学士，副主任医师．研究方向：妇科内镜
