摘要
目的:以金花清感颗粒为代表方评价治疗流行性感冒风热犯肺证中药的临床合适剂量。方法:在6个中心选取流感风热犯肺证患者,随机给予金花清感颗粒高剂量、常规剂量或安慰剂治疗5 d,进行双盲对照评价。结果:观察有效病例136例,统计显示金花清感颗粒常规剂量组(n=45)的退热时间短于安慰剂组(n=47);中医综合疗效在用药3 d、5 d后常规剂量组都优于安慰剂组;高剂量组(n=44)疗效与常规剂量组近似,在部分疗效指标方面略差。3组间不良事件与不良反应比较差异无统计学意义。结论:金花清感颗粒所推荐的常规剂量是其合适剂量,增大剂量并不提高疗效。
Objective：To study the optimal dosage of JinhuaQinggan Granule （JHQG） in treating influenza fever with wind-heat affecting lung symptom-complex （WHALS）. Methods： Influenza patients with WHALS were enrolled from 6 clinical center of the study. They were randomized divided into 3 group, high dosage group, low dosage group and the placebo group, then they receive 5 days medication before valuation. Results： 136 cases confirmed with influenza were enrolled, statistical analysis shows low dosage group of JHQG significant reduced the estimated median time to fever resolution compared with the placebo group, synthesize Chinese medical curative effect in low dosage group is better that of placebo group at the 3th and 5th day from treatment. High dosage group has a similar effect with low dosage group except inferior to partial criteria. There is no significant difference about side effects among these three groups. Conclusion：Low dosage is the optimal dosage of JHQG, high dosage medication cannot promote the curative effect.
出处
《中国中医基础医学杂志》
CAS
CSCD
北大核心
2013年第11期1328-1330,F0004,共4页
JOURNAL OF BASIC CHINESE MEDICINE
基金
国家科技重大专项课题-中药新药临床研究技术平台规范建设(2008ZX09312012)
关键词
金花清感颗粒
流行性感冒
风热犯肺证
剂量效应关系
随机对照研究
JinhuaQinggan Granule
influenza
wind-heat affecting lung symptom-complex
randomized
doubleblinded
placebo controlled
dosage-efficacy relationship
作者简介
通讯作者：边永君（1970-），男，主任医师，医学博士，Tel：010—88001019，E-mail：drbianyj@yahoo．com．cn。
