摘要
目的探讨甲胎蛋白异质体(AFP-L3)对原发性肝癌(primary liver cancer,PLC)患者肝癌切除术后肿瘤复发转移的预测价值。方法选择2008年6月至2009年12月期间在我院接受首次肝癌切除术的48例PLC患者,同步测定患者术前、术后血清AFP和AFP-L3含量,计算AFP-L3占总AFP的百分比(以AFP-L3%≥10%作为阳性判断标准)。并对患者进行长期复查和随访,以了解血清AFP和AFP-L3对PLC患者肝癌切除术后肿瘤复发转移的预后判断价值。结果 48例PLC患者在随访期间共有25例发生肿瘤复发转移,随访1、2、3年的总体复发率分别为22.9%(11/48)、39.6%(19/48)、52.1%(25/48)。患者术前血清AFP-L3%与总AFP水平之间无相关性;术前、术后血清AFP-L3%与肿瘤复发转移之间均呈正相关,而术前、术后血清AFP水平与肿瘤复发之间缺乏明确的相关性。结论血清AFP-L3%与肝癌切除术后肿瘤复发有关联,对PLC患者术后复发转移的判断有重要临床价值。
Objective To discuss the value of AFP-L3 in serum for predicting recurrence and transfer of PLC post-operative. Methods Totally48 patients,with primary liver cancer （PLC） , received surgical resection from July2008 to December2009 were enrolled in the present study. The detailed clinical data were obtained for each patient. Pre-and post-operative AFP and AFP-L3 levels in serum were measured continuously, and the proportions of AFP -[3 were calculated （with cut-off value t〉 10% for AFP -I3 is positive）. The patterns of their post-operative changes were followed up for a long-term period. Results 25cases occured tumor recurrence during the follow-up period in 48 patients with PLC. The recurrence rates of the patients during the first 3 years were 22.9% （ 11/48）, 39.6% （ 19/45 ）, 52. 1% （ 25/48 ） respectively. There was no relative relationship between serum AFP and AFP-L3 level before operation. The pre- and post-operation serum AFP-I3 level was significantly correlated with tumor recurrence, but the relation between pre- and post- operation serum AFP level and tumor recurrence was not clear yet. Conclusions Serum AFP-L3 level is associated with PLC recurrence and therefore valuable for predicting PLC recurrence.
出处
《齐齐哈尔医学院学报》
2013年第21期3128-3130,共3页
Journal of Qiqihar Medical University
基金
清远市科技计划项目(项目编号:2012B011204121)
关键词
甲胎蛋白异质体
原发性肝癌
肿瘤复发
预测价值
Alpha-fetoprotein-L3
Primary liver cancer
Neoplasms recurrence
Predictive value
