摘要
该文以低相对分子质量壳聚糖和泊洛沙姆188为联合载体,采用溶剂法制备人参皂苷Rg3固体分散体,进行体外溶出试验,并通过差示扫描量热法(DSC)、扫描电镜(SEM)和X-射线衍射法(X-RD)进行物相分析。结果表明,低相对分子质量壳聚糖和泊洛沙姆188按2∶1制备的人参皂苷Rg3固体分散体60 min药物的体外累积溶出率达到90%以上,且药物以非晶状态分散于载体中。因此,以低相对分子质量壳聚糖和泊洛沙姆188为联合载体制备的人参皂苷Rg3固体分散体能够显著提高药物的溶出度,具有实际应用价值。
With low molecular weight chitosan and poloxamer 188 as the joint carriers, ginsenoside Rg3 solid dispersions were prepared by using the solvent evaporation method for an in vitro dissolution test. Subsequently, differential scanning calorimetry （DSC）, scanning electron microscopy（SEM） and X-ray diffraction （X-RD） were adopted for a phase analysis. The results showed that the 60 min in vitro cumulative dissolution rate of ginsenoside Rg3 solid dispersions prepared with low molecular weight chitosan and poloxamer 188 at the ratio of2：1 exceeded 90%, and the drag was dispersed in carriers in an amorphous state. Therefore, ginsenoside Rg3 solid dispersions prepared with low molecular weight chitosan and poloxamer 188 could help significantly improve the drag dissolution, with a practical application value.
出处
《中国中药杂志》
CAS
CSCD
北大核心
2013年第24期4298-4302,共5页
China Journal of Chinese Materia Medica
基金
江苏省中医药领军人才项目(2006)
国家中医药管理局中药口服制剂释药系统重点研究室开放基金课题(2011NDDCM01002)
作者简介
刘其媛，硕士研究生，研究方向为中药药剂新剂型研究，Tel：15850530729，E—mail：lqiyuan670@163．com
[通信作者]贾晓斌,TeL／Fax（025）85637809，E-mail：jxiao-Kn2005@hotmail．com
