摘要
急性胰腺炎患者并发肠屏障功能障碍与病情的加重和死亡率增高密切相关。保护急性胰腺炎患者的肠屏障功能是急性胰腺炎的一项重要治疗措施。临床上可通过测定肠道通透性或血清标志物等来反映肠屏障功能。肠屏障功能障碍的机制主要是缺血/再灌注损伤、炎症、胃肠动力障碍。防治措施包括:适当地液体复苏、抗氧化应激减轻缺血/再灌注损伤,抗炎性介质,肠内营养以及中医中药治疗等。
The intestinal barrier dysfunction is closely associated with aggravation and increasing mortali- ty in acute pancreatitis. It is an important treatment of acute pancreatitis to protect intestinal barrier function in patients with acute pancreatitis. In clinical, the intestinal barrier function can be reflected by measuring intestinal permeability or serum biomarkers. The mechanism of intestinal barrier dysfunction mainly includes ischemia/reperfusion injury, inflammation, and gastrointestinal motility disorders. Prevention and control measures include appropriate fluid resuscitation, anti-oxidative stress and ischemia/reperfusion injury, anti-inflammatory medium, enteral nutrition, and Chinese medicine treatment.
出处
《医学综述》
2013年第20期3737-3739,共3页
Medical Recapitulate
关键词
急性胰腺炎
肠屏障功能障碍
肠道通透性
Acute pancreatitis
Intestinal barrier dysfunction
Intestinal permeability
