摘要
采用冷冻聚合法制备了多孔结构的P(NIPAm-co-AAm)智能水凝胶,选用牛血清白蛋白(BSA)为模型药物分子,通过后包裹技术负载蛋白质药物,考察了多孔水凝胶中蛋白质药物的载药量和体外释放行为,研究了不同干燥处理方法对载药后水凝胶的药物控释性能的影响,并且与传统方法制备的P(NIPAmco-AAm)水凝胶进行了药物控释性能对比实验。实验结果表明,在凝胶中引入多孔结构使得P(NIPAm-coAAm)水凝胶的药物载药量和释放量得到了显著的提高。不同的干燥处理方法对多孔P(NIPAm-co-AAm)水凝胶的药物释放影响很大,载药后的凝胶采用冰箱冷冻干燥处理,可使蛋白质药物有较好的缓释效果。
Porous poly （N-isopropylamide-co-acrylamide） [_ P （NIPAm-co-AAm） J hydrogels were preparect Dy freezing polymerization method. With bovine serum albumin （BSA） as the model drug, it was loaded into por- ous P （NIPAm-co-AAm） hydrogel by post-fabrication encapsulation technique. The loading efficiency and re- lease ratio of model drug were investigated. The influence of different dry processing method on the controlled drug release properties of the drug-loaded hydrogel was also studied. The results showed that creating an inter- connecting pore structure within the hydrogel matrices was an effective strategy to improve the drug loading ef- ficiency and the cumulative released amount. In vitro BSA release from the hydrogels exhibited that dry pro- cessing method played a dominant role in the controlled drug release properties of P（NIPAm-co-AAm） hydro- gel. The drug-loaded hydrogel with the refrigerator freeze-drying treatment showed better sustained drug re- lease of protein drugs.
出处
《功能材料》
EI
CAS
CSCD
北大核心
2013年第21期3085-3088,共4页
Journal of Functional Materials
基金
国家自然科学基金资助项目(51102200)
重庆市教委科学技术研究资助项目(KJ130108
KJ120106)
重庆高校创新团队建设计划资助项目(KJTD201301)
西南政法大学校级资助项目(2011-XZQN11)
作者简介
杨桔（1979-），女，湖南邵阳人，讲师，博士，主要从事智能材料、纳米材料合成方面研究。
