摘要
目的 观察两种不同剂量二甲硅油散在结肠镜检查前服用对肠腔的去泡能力及不良反应.方法 120例行结肠镜检查的门诊患者随机分为3组,各组患者均采用标准剂量磷酸钠作肠道准备,对照组仅采用标准剂量磷酸钠作肠道准备;试验Ⅰ组先采用标准剂量磷酸钠作肠道准备完成后,再采用150mg二甲硅油散溶入温水50ml口服;试验Ⅱ组先采用标准剂量磷酸钠作肠道准备完成后,再采用300mg二甲硅油散（健亨）溶入温水50ml口服.对于肠道清洁度及各肠段泡沫进行盲法评价,记录息肉发现情况,并观察有无良反应.结果 对照组22.5％～40％的患者肠道中无或有少许泡沫,而试验Ⅰ组有95％～97.5％、试验Ⅱ组有97.5％～100％,对照组与两试验组比较差异有显著性（P＜0.05）,两试验组间比较差异无显著性（P＞0.05）,对照组还有相当比例达到2、3级泡沫,明显影响观察,两种剂量二甲硅油散均能良好地消除泡沫,使结肠镜检查时肠道能见度提高.对照组由于有较多患者有泡沫,影响观察.两试验组95％以上有极少量或没有泡沫,较易发现较小病变.各组均无明显不良反应.结论 国产二甲硅油散能显著减少磷酸钠作结肠镜检查术前肠道准备时肠道泡沫;较低剂量二甲硅油散就能达到满意效果.
Objective To evaluate the effect of two dosages of the dimethicone to remove bubbles in bowel preparation before colonoscopy,and observe its possible adverse effects.Methods 120 out-patients received colonoscopy were randomly divided into the two study groups and the control group.The control group only used a standard dosage of sodium phosphate for bowel preparation.The study group 1 was given 150mg simethicone after sodium phosphate and the study group 2 was given 300mg simethicone after sodium phosphate.Intraluminal gas bubbles were graded in different bowel section and any possible adverse effects were monitored.Results There were only 22.5％-40％ patients have no or a little intraluminal gas bubbles in the control group but there are 95％-100％ in the study group 1 and 2（P＜0.05）.There was no significant difference between the two study groups（P＞0.05）.No adverse effects were observed.Conclusion The dimethieone administration before colonoscopy significantly reduces intraluminal gas bubbles and improves the visualization of the intestinal mucosa.A small dosage of dimethieone is enough to achieve the good effect.
出处
《西部医学》
2013年第11期1680-1682,共3页
Medical Journal of West China
