摘要
目的 :观察灵杆菌素对肿瘤化疗后白细胞减少的治疗作用及不良反应。方法 :收集80例癌症患者临床资料 ,其中包括肺癌、非霍奇金淋巴瘤瘤、乳腺癌、头颈部癌、白血病等病种 ,随机分为灵杆菌素治疗组和惠尔血对照组 ,对比观察两组白细胞的变化及不良反应。结果 :两组治疗对化疗后白细胞减少的疗效无显著差异 ,灵杆菌素的不良反应主要为发热、骨骼肌肉疼痛、皮疹、局部硬结 ,患者均能耐受 ,与惠尔血的不良反应无明显差异。结论 :灵杆菌素对化疗后白细胞减少的治疗作用与惠尔血相似 ,毒性可耐受 ,价格便宜 。
Objective:To evaluate the effect of prodigiosin in treating leucopenia caused by cancer chemotherapy,and to obseve the side effects of the drug.Method:80 patients with malignancies including lung cancer,non Hodgkin's lymophoma,breast cancer,head and neck cancer,and leukemia.All the patients were divided into the Prodigiosin group and the G CSF group randomly.The change of white blood cell (WBC) count between two groups was compared.We also contrasted the effects and toxicity of Prodigiosin versus G CSF.Result:The effects of Prodigiosin were similar to G CSF.The side effects of Prodigiosin including fever,chill,skeleton and muscle pain,rashes and local thickness of injection site which were all mild to moderate.The frequencies of side effect were not siginficantly different between prodgiosin and G CSF.Conclusion:The effects of prodigiosin were similar to G CSF in treating leucopenia caused by cancer chemotherapy.The toxicity was tolerable.It's cheap and worth spreading in clinical practice.
出处
《四川肿瘤防治》
2000年第4期242-244,共3页
Sichuan Journal of Cancer Control
