摘要
目的探讨手术联合放疗治疗喉癌的疗效及影响预后的因素。方法回顾性分析92例接受手术及术后放疗的喉癌患者的临床资料。Log-rank检验进行生存分析,Cox回归模型进行多因素分析。结果 92例喉癌患者的1、3、5、10年生存率分别为85.9%、72.6%、67.5%和60.9%,1、3、5、10年局部控制率分别为93.3%、81.3%、75.6%和57.6%。单因素分析结果显示,年龄、颈部淋巴结转移与喉癌患者的预后有关(P<0.05)。Cox回归多因素分析显示,颈部淋巴结转移是影响喉癌患者预后的独立因素。结论颈部淋巴结转移是影响喉癌患者手术联合放疗预后的独立因素。提高局部控制率、加强术后随访是提高生存率及改善生活质量的关键。
Objective To evaluate the efficacy and prognostic factors of laryngeal cancer patients treated by surgery combined with radiotherapy.Methods Clinical data of 92 patients with laryngeal cancer treated by surgery and radiotherapy in Anhui provincial hospital were analyzed retrospectively.Log-rank test and Cox multivariate model were used to analyze the prognostic factors.Results The 1-,3-,5-,10-year survival rates were 85.9％,72.6％,67.5％ and 60.9％,and the 1-,3-,5-,10-year locoregional relapsefree survival were 93.3％,81.3％,75.6％ and 57.6％.In univariate analysis,the survival was related to patients＇ age and postoperative lymph node metastasis.In Cox multivariate model,postoperative lymph node metastasis was an independent prognostic factor.Conclusion The postoperative lymph node metastasis is an independent prognostic factor for patients with laryngeal cancer after combined treatment.Postoperative follow-up and the improvement of locoregional relapse-free survival is important to improve the survival of patients with laryngeal cancer.
出处
《临床肿瘤学杂志》
CAS
2013年第10期910-913,共4页
Chinese Clinical Oncology
关键词
喉癌
多因素分析
预后因素
Laryngeal cancer
Mulitvariate analysis
Prognosis factors
作者简介
通讯作者，E-mail：money2004@sina．com
