摘要
目的:探讨不同疗程复合乳酸菌胶囊对根除幽门螺杆菌(Helicobacter pylori,H.pylori)疗效的影响.方法:H.pylori阳性的慢性胃炎、消化性溃疡患者200例,分为对照组、短疗程组、中疗程组、长疗程组,每组50例.对照组予雷贝拉唑、克拉霉素、阿莫西林三联治疗7 d;短疗程组、中疗程组、长疗程组在上述标准三联、7 d疗法开始治疗的同时分别加用复合乳酸菌胶囊,分别服用1、2、4 wk.停用复合乳酸菌胶囊4 wk后复查H.pylori,比较各组的H.pylori根除率、药物不良反应发生率.结果:共195例按试验设计完成治疗和随访.短疗程组H.pylori根除率(64.0%)与对照组(62.5%)无显著差异(P>0.05),中疗程组(83.7%)、长疗程组(85.4%)根除率均高于对照组,差异有统计学意义(P<0.05).中疗程组根除率略低于长疗程组,但差异无统计学意义.各组不良反应发生率均较低且差异无显著性.结论:联用复合乳酸菌胶囊能显著提高H.pylori根除率,2 wk左右的疗程为最佳的选择.
AIM： To observe the clinical efficacy of different durations of therapy with composite lactobacillus capsules in Helicobacter pylori（H.pylori）eradication.METHODS： Two hundred H.pylori-positive patients with chronic gastritis or peptic ulcer were randomly divided into a control group,a short course group,a middle course group and a long course group.The control group underwent standard triple therapy（raberazole,clarithromycin and amoxicillin for 7 d）.Composite lactobacillus capsules were additionally given to the short course group,middle course group and long course group for 1,2,and 4wk on the basis of standard triple therapy,respectively.The14C urea breath test was performed 4 wk after all drugs were stopped.The rate of H.pylori eradication and safety were evaluated.RESULTS： In total,195 patients completed the treatment and follow-up according to the experimental design.There was no difference in the rate of H.pylori eradication between the short course group and control group（64.0% vs 62.5%,P 0.05）.The eradication rate was significantly higher in the middle course group and long course group than in the control group（83.7%,85.4% vs 62.5%,both P 0.05）,but there was no significant difference between the middle course group and long course group.Adverse reactions were slight in all the groups,and there was no significant difference in the rate of adverse reactions between different groups.CONCLUSION： Composite lactobacillus capsules with triple therapy can improve the rate of H.pylori eradication.Two weeks is the best course of treatment.
出处
《世界华人消化杂志》
CAS
北大核心
2013年第28期3037-3040,共4页
World Chinese Journal of Digestology
关键词
复合乳酸菌胶囊
雷贝拉唑
克林霉素
阿莫西林
幽门螺杆菌
Composite lactobacillus capsules
Rabera-zole
Clarithromycin
Amoxicillin
Helicobacterpylo#
作者简介
罗宜辉，主治医师，主要从事消化内镜及幽门螺杆菌防治工作．通讯作者：罗宜辉，主治医师，545006，广西壮族自治区柳州市文昌路8号，广西科技大学附属柳州市人民医院消化内科2病区lyhl45@aliyuncom电话：0772—2662769
