血清乙型肝炎表面抗原水平预测慢性乙型肝炎病毒感染状态的研究进展被引量：3

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摘要乙型肝炎表面抗原（hepatitis B surface antigen,HBsAg）的发现显著提高了乙型肝炎的诊断水平。早期开展的血清HBsAg检测属于定性检测,HBsAg阳性表示存在乙型肝炎病毒（hepatitis B virus,HBV）感染,但不能判断HBV感染状态。血清HBsAg定量检测始于增敏化学发光技术的引入。

作者陆伟张占卿

机构地区上海市公共卫生临床中心肝炎二科

出处《临床荟萃》 CAS 2013年第10期1185-1190,共6页 Clinical Focus

基金国家"863"高技术研究发展计划生物和医药领域重大/重点基金(2006AA02A411)

关键词肝炎乙型肝炎表面抗原乙型诊断鉴别

分类号 R512.62 [医药卫生—内科学]

作者简介通信作者：张占卿，Email：doctorzzqsphc@163．com

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1Whitehead TP,Thorpe GHG,Carter TJN,et al.Enhanced luminescence procedure for sensitive determination of peroxidase-labelled conjugates in immunoassay[J].Nature,1983,305(5930):158-159.
2Deguchi M,Yamashita N,Kagita M,et al.Quantitation of hepatitis B surface antigen by an automated chemiluminescent microparticle immunoassay[J].J Virol Methods,2004,115(2):217-222.
3Rodella A,Galli C,Terlenghi L,et al.Quantitative analysis of HBsAg,IgM anti-HBc and anti-HBc avidity in acute and chronic hepatitis B[J].J Clin Virol,2006,37(3):206-212.
4Galli C,Orlandini E,Penzo L,et al.What is the role of serology for the study of chronic hepatitis B virus infection in the age of molecular biology?[J].J Med Virol,2008,80(6):974-979.
5Brunetto MR,Moriconi F,Bonino F,et al.Hepatitis B virus surface antigen levels:a guide to sustained response to peginterferon alfa-2a in HBeAg-negative chronic hepatitis B[J].Hepatology,2009,49(4):1141-1150.
6Moucari R,Mackiewicz V,Lada O,et al.Early serum HBsAg drop:a strong predictor of sustained virological response to pegylated interferon alfa-2a in HBeAg-negative patients[J].Hepatology,2009,49(4):1151-1157.
7Patient R,Hourioux C,Roingeard P.Morphogenesis of hepatitis B virus and its subviral envelope particles[J].Cell Microbiol,2009,11(11):1561-1570.
8赵秀英.血清HBsAg定量检测及探讨——从检验者角度看HBsAg定量[J].北京医学,2010,32(3):216-218. 被引量：11
9Liaw YF.Natural history of chronic hepatitis B virus infection and long-term outcome under treatment[J].Liver Int,2009,29(Suppl 1):100-107.
10Chu CM.Liaw YF.Predictive factors for reactivation of hepatitis B following hepatitis B e antigen seroconversion in chronic hepatitis B[J].Gastroenterology,2007,133(5):1458-1465.

二级参考文献18

1申群喜,祝玲玲,苏黎,曾云,朱平安.电化学发光法HBsAg定量分析最适稀释度及其与HBV-DNA含量关系的探讨[J].湖南师范大学学报（医学版）,2006,3(2):16-19. 被引量：4
2Tate J, Ward G. Interferences in immunoassay. Clin Biochem Rev,2004,25:105-120.
3ASSLD PRACTICE GUIDELINES (Chronic Hepatitis B ) http://www.aasld.org/practiceguidelines/Pages/ViralHepatitis.aspx.
4Manesis EK, Hadziyannis ES, Angelopoulou OP, et al. Prediction of treatment-related HBsAg loss in HBeAG-negative chronic hepatitis B: a clue from serum HBsAg levels. Antivir Ther,2007,12:73-82.
5Brunetto MR, Moriconi F, Bonino F, et al. Hepatitis B virus surface antigen levels: a guide to sustained response to pegintederon alfa-2a in HBeAg-negative chronic hepatitis B. Hepatology,2009,49:1141-1150.
6Marcellin P, Lada O, Asselah T. Treatment of chronic hepatitis B with the combination of pegylated interferon with lamivudine. Hepatol Res,2007,37:S55-61.
7Rosenau J, Kreutz T, Kujawa M, et al. HBsAg level at time of liver transplantation determines HBsAg decrease and anti-HBs increase and affects HBV DNA decrease during early immunoglobulin administration. J Hepatol,2007,46:635-644.
8Volz T, Lutgehetmann M, Wachtler P, et al. Impaired intrahepatic hepatitis B virus productivity contributes to low viremia in most HBeAg-negative patients.Gastroenterology,2007,133:843-852.
9La'ulu SL, Roberts WL. The analytic sensitivity and mutant detection capability of six hepatitis B surface antigen assays.Am J Clin Pathol,2006,125:748 -751.
10Andersson KL, Chung RT. Monitoring during and after antiviral therapy for hepatitis B. Hepatology,2009,49:S166-173.