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靶向c-FLIP在癌症治疗中的分子调节机制 被引量：1

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摘要 凋亡对于维持组织的自稳态和正常发育非常重要。与凋亡相关的信号通路主要有两个：一个是配体结合诱导的外部凋亡通路,另一个是线粒体依赖的内部凋亡通路。c-FLIP是外部凋亡通路中的一个重要负调控因子,它的13个剪切突变体基因已经被鉴定,但是只有三个能翻译成蛋白质（c-FLIP L、cFLIP和c-FLIP）。
作者 王琪琳
机构地区 聊城大学生命科学学院
出处 《中国免疫学杂志》 CAS CSCD 北大核心 2013年第9期998-1002,共5页 Chinese Journal of Immunology
基金 国家自然基金(20971063)资助
关键词 C-FLIP 分子调节机制 凋亡通路 治疗 癌症 靶向 负调控因子 CFLIP
分类号 Q28 [生物学—细胞生物学]
作者简介 王琪琳（1972年-），女，博士，副教授，主要从事肿瘤细胞信号转导及抗肿瘤药物筛选机制的研究，E—mail：wql@lcu．edu．cn。
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参考文献50

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中国免疫学杂志
2013年 第9期

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