摘要
长链非编码RNAs(lncRNAs)是在基因组中普遍被转录的一类转录本长度超过200 nt的非编码蛋白RNA。近年来的研究表明,lncRNAs参与了X染色体沉默、基因组印记以及染色质修饰、转录激活、转录干扰和核内运输等多种重要的调控过程,这表明lncRNAs并不是基因组转录的"噪音",而是以RNA的形式在多层面上(表观遗传调控、转录调控以及转录后调控等)调控基因的表达水平。该文总结lncRNAs的功能及其调控血管新生的最新研究进展。
Long non-coding RNAs （lncRNAs） are a novel class of non-protein-coding transcript RNAs with more than 200 nt in length, which are pervasively transcribed in the genome. Recent researches have demonstrated that lncRNAs affect many biological processes, including X-inactivation, genomic imprinting, chromatin-modifying, transcriptional activation, transcriptional interference and nuclear-cytoplasmic trafficking, which indicates lncRNAs are not transcriptional noise but functional as a regulater of the gene expression on the epigenetie, transcriptional and post-transcriptional levels. The research progress of lncRNAs functions and their role in the regulation of angiogenesis is reviewed in this paper.
出处
《上海交通大学学报（医学版）》
CAS
CSCD
北大核心
2013年第9期1301-1305,共5页
Journal of Shanghai Jiao tong University:Medical Science
基金
国家自然科学基金(81160154
81272170)~~
作者简介
刘鹃（1987-），男，硕士生；电子信箱：pajingsen@126．com。
[通信作者]邓志锋，电子信箱：dengzf63@126．com。
