摘要
目的观察高血压患者血浆中脂蛋白相关磷脂酶A2(LP-PLA2)水平,探讨它与EH的关系及其临床意义。方法选择原发性高血压病患者120例。按临床诊断分为:1级30例,2级43例,3级47例;又据危险分层分为:低中危组33例,高危组38例,极高危组49例;健康对照组40例,测定脂蛋白相关磷脂酶A2(LP-PLA2),并记录高敏C反应蛋白(hs-CRP)、血脂等临床指标。结果高血压组LP-PLA2水平显著高于对照组,极危组中LP-PLA2水平显著高于高危组和低中危组,差异有统计学意义(P<0.01);LP-PLA2与危险分层、收缩压、舒张压、低密度脂蛋白胆固醇(LDL-C)呈显著的正相关(P<0.05)。结论外周血浆中LP-PLA2水平随血压的升高而升高,它可能参与了高血压的发生、发展过程。
Objective To observe the level of LP-PLA2 in the plasma of patients with hypertension,and to explore its relationship with EH and its clinical significance.Methods Totally 120 EH patients were selected and graded by clinical diagnosis：stage Ⅰ 30 cases,stage Ⅱ 43 cases,stage Ⅲ 47 cases; graded by risk stratification：low-risk group 33 cases,high-risk group 38 cases,very high-risk group 49 cases.Forty cases were in the control group.Lipoprotein-associated phospholipase A2 （LP-PLA2）,high-sensitivity C -reactive protein （hs-CRP）,lipids and other clinical parameters were detected.Results LP-PLA2 of hypertension group were significantly higher than that in the control group,and LP-PLA2 of very high-risk group were significantly higher than that in high-risk group and low-risk group （P 〈 0.01）.LP-PLA2 showed a significant positive correlation with risk stratification,systolic blood pressure,diastolic blood pressure,and low-density lipoprotein cholesterol （LDL-C） （P 〈 0.05）.Conclusion LP-PLA2 in peripheral blood increased with the severity of hypertension.It may be involved in the occurrence and development of hypertension.
出处
《医学研究杂志》
2013年第9期147-149,共3页
Journal of Medical Research
关键词
高血压
磷脂酶A2
危险因素
炎症
Hypertension
Phospholipase A2
Risk Factors
Inflammation
作者简介
通讯作者：刘丽娟，电子信箱：gzq123xyz@126．com
