摘要
目的:探讨更昔洛韦联合地塞米松或者白细胞介素-2(IL-2)治疗带状疱疹的临床效果。方法:将201例带状疱疹患者随机分为A、B、C三组,每组各67例。A组采用更昔洛韦联合地塞米松治疗,B组采用更昔洛韦联合IL-2治疗,C组采用三者联合治疗。结果:治疗后三组患者均较治疗前疼痛状况明显减轻(P<0.05)。治疗后3d、5d的疼痛评分由高至低依次为B组、A组、C组(P<0.05)。A组疼痛停止时间显著早于B组(P<0.05),但两组间止疱、结疱时间的差异无统计学意义(P>0.05)。C组疼痛停止时间,止疱、结疱时间最早(P<0.05)。A、B、C组的临床有效率分别为95.5%、94.0%、97.0%(P>0.05),后遗神经痛的发生率分别为1.5%(1例)、3.0%(2例),0.0%(0例)(P>0.05)。各组均未观察到严重不良反应的发生。结论:更昔洛韦联合地塞米松及IL-2治疗带状疱疹可以显著缓解疼痛,临床有效率高,后遗神经痛的发生率低,且无明显不良反应发生。
Objective： To investigate the effects of ganciclovir combined with dexamethasone or interleukin -2 （IL -2） in the treatment of herpes zoster. Methods： The 201 cases with herpes zoster were randomly divided into A , B and C group, 67 cases per group. The A group were recived ganciclovir and dexamethasone treatment, B group with ganciclovir and IL -2 , and C group recived ganciclovir combined with dexamethasone and IL - 2. Results： The scores of the three group after treatment were significantly reduced than before treatment. （ P 〈 0.05）. The 3d, 5d pain scores of the B, A, C group were decreasing in order （P 〈 0. 05 ）. The third day and fifth day SAS scores of the A group were significantly lower than those of the B group （ P 〈 0. 05 ）. The pain stop time of group A was significantly earlier than that of group B （P 〈 0. 05 ） ; but the stop blisters time and blisters scab time between the two groups were no significant difference. （P 〉 0.05 ）. The pain stop time, the stop blisters time and blisters scab time of C group was earliest （ P 〈 0. 05 ）. The clinical response rate of group A, B and C group was 95.5 % , 94.0%, 97. 0% respectively （ P 〉 0. 05 ）, the inci- dence of postherpetic neuralgia was 1.5% （ 1 case）, 3.0% （2 cases） and 0. 0% （0cases） respectively （P 〉0. 05）. There was no serious adverse reactions observed in the three groups. Conclusion： The ganciclovir combined with dexamethasone and IL -2 treat- ment of herpes zoster can significantly relieve pain and have high clinically effective rate, with low incidence of postherpetic neuralgia and no serious adverse reactions.
出处
《中国民族民间医药》
2013年第17期21-22,共2页
Chinese Journal of Ethnomedicine and Ethnopharmacy
关键词
带状疱疹
更昔洛韦
白细胞介素
地塞米松
疗效评价
herpes zoster
ganciclovir
interleukin
dexamethasone
evaluate clinical result
作者简介
郭江琴（1970-），女，江苏扬中人，主治医师，主要从事皮肤病、性病学临床研究。
