摘要
目的了解惠州市甲型H1N1流感流行状况,为有效防控甲型H1N1流感提供参考依据。方法运用描述流行病学方法分析2009～2012年惠州市甲型H1N1流感流行状况;用血清流行病学方法调查惠州市人群甲型H1N1流感病毒的感染水平。结果 2009～2012年惠州市流感监测哨点医院的平均ILI就诊百分比(ILI%)为7.88%,共报告甲型H1N1流感279例。采集鼻咽拭子2 230份,甲型H1N1流感核酸检测阳性219份,阳性率为9.82%,阳性率最高的年龄组为15～岁组(24.45%),最低的年龄组为0～岁组(3.43%)。三次横断面调查共抽取调查对象480人,甲型H1N1流感病毒抗体阳性人数121人,阳性率为25.21%。三次调查抗体阳性率分别为30.0%,36.25%和9.38%,人群甲型H1N1流感抗体阳性率在年龄、性别及职业间差异有统计学意义(P<0.05);接种过甲型H1N1流感疫苗和未接种过甲型H1N1流感疫苗之间的抗体阳性率差异有统计学意义(χ2=71.76,P<0.05)。结论惠州市甲型H1N1流感疫情通过采取综合性措施得到有效防控,今后应定期在人群中开展流感病毒抗体监测,以便了解人群对流感流行株的免疫保护和病毒抗原变化,为防控流感提供重要依据。
Objective To investigate the epidemic situation of influenza A （HIN1）in Huizhou and to provide a scientific basis for making prevention and control measures. Methods The epidemic situation of influenza A（H1N1）in Huizhou from 2009-2012 was analyzed by descriptive epidemiology, and the infection levels of influenza A （H1N1 ）virus in the population were also investigated by serum epidemiology. Results The average proportion of ILl cases in total outpatients was 7.88% in sentinel hospitals,279 H1N1 cases were reported from 2009-2012. 2 230 nasopharyngeal swab specimens were coUected. 219 （9.82%）were positive for pandemic influenza A （H1N1）virus. The highest positive rate was found in the age greup-15（24.45%）,while the lowest（3.43%）was found in the age group less than 5 years. 480 people were investigated in the three surveys,and positive antibody to influenza A（H1N1 ）virus were detected in 121 of them,with a total positive rate of 25.21%. The positive rates in the surveys were 30.0%,36.25% and 9.38%,respectively,showing statistically significant differences in age groups, sex and occupations （P〈0.05）. The positive rate in population vaccinated with influenza A（H1N1）vaccine was significantly higher than that without vaccinated（x^2=71.76,P〈0.05）. Conclusions The spread of influenza A （H1Nl）virus in Huizhou ha been got under effective control through comprehensive management measures. Regular monitoring the level of the antibody of influenza in a population would be conducive to understanding the immune protection against epidemic strains of influenza virus and the changes of viral antigens for providing an essential basis for the prevention and control of influenza.
出处
《中国热带医学》
CAS
2013年第8期953-956,共4页
China Tropical Medicine
基金
"十二五"国家科技重大专项(2012ZX10004213)
关键词
甲型H1N1流感
血清抗体
感染状况
血凝抑制试验
Influenza A（H1N1）
Serum antibody
Infection status
Hemagglutination-inhibitian assay
作者简介
琚雄飞，男，博士，副主任技师，主要从事疾病防控及病原微生物检验。
