摘要
目的探讨磁共振T2及T2*弛豫时间图成像评估膝关节软骨运动前后变化的可行性及应用价值。方法20名年轻健康志愿者进行运动前后的膝关节软骨T2及T2*弛豫时间图成像,测量股骨内侧髁承重区、内侧髁后部非承重区、股骨外侧髁承重区、外侧髁前部非承重区、外侧髁后部非承重区及胫骨内侧平台、外侧平台7个不同区域软骨全层、浅层及深层的T2及T2*值,各区域关节软骨全层、浅层及深层运动前后的T2(T2*)值进行配对t检验,运动前关节软骨浅、深层T2(T2*)值进行独立样本t检验,并对各区域相同感兴趣区T2与T2*值进行Spearman相关性分析。结果股骨外侧髁承重区和内侧髁后部非承重区全层软骨,股骨外侧髁承重区、外侧髁后部非承重区、内侧髁承重区及内侧髁后部非承重区浅层软骨,股骨内侧髁后部非承重区深层软骨的运动前后平均T2值,以及股骨外侧髁承重区、外侧髁前部非承重区、内侧髁后部非承重区和胫骨内侧平台全层软骨,股骨外侧髁承重区、外侧髁前部非承重区、内侧髁承重区、内侧髁后部非承重区、胫骨内侧平台和外侧平台浅层软骨,胫骨内侧平台深层软骨的运动前后平均T2*值均存在显著差异(P<0.05),运动后T2值及T2*值较运动前降低。膝关节7个不同区域运动前相同部位软骨浅深层T2及T2*值有非常明显统计学差异(P<0.001),浅层软骨均较深层软骨T2及T2*值升高。在运动前后的42个感兴趣区中,共有29个感兴趣区层面的T2与T2*值存在相关性(P值<0.05),尤其在浅层软骨区域二者相关性相对更明显。结论 T2及T2*弛豫时间图成像均有助于对关节软骨内生化成分及微观结构变化的量化评估,具有进一步的临床应用价值。
Objective To explore the feasibility and value of magnetic resonance （MR） T2 and T2 star（T2 ＊ ） mapping in evaluating cartilage matrix changes of the knee joint after exercise. Methods MR T2 and T2 ＊ maps of articular cartilage were obtained in 20 young healthy volunteers before and immediately after exercise by using a 3.0 T MRI. Lateral femoral condyle and medial femoral condyle compartments were partitioned into anterior and posterior nonweight bearing （ant nwb and post nwb） zones and weight bearing （wb） zones in all subjects. Cartilage T2 and T2＊ values of femoral condyle and tibia were quantified in full thickness, superficial and deep layers of seven defined subcompartments. Statistical analysis of T2 and T2 ＊ variance and correlation in matched regions was performed. Results There was a statistically significant decrease of T2 values in the full thickness cartilage of lateral femoral condyle （wb） and medial femoral condyle （ post nwb）, as well as in the superficial layers of lateral femoral condyle （ wb and post nwb） and medial femoral condyle （ wb and post nwb）, and in the deep layers of medial femoral condyle（ post nwb） after exercise. Significant decrease of T2 ＊ values were also be shown in the full thickness cartilage of lateral femoral condyle （wb and ant nwb）, medial femoral condyle （post nwb） and medial tibia, as well as in the superficial layers of lateral femoral condyle（ wb and ant nwb）, medial femoral condyle （ wb and post nwb）, lateral tibia and medial tibia, and in the deep layers of medial tibia. T2 and T2 ＊ values of superficial layers in seven defined subcompartments were significantly elevated compared with those of deep layers. The correlation between T2 and T2 ＊ was significant, particularly in the superficial layers. Conclusion T2 and T2 ＊ mapping can assess the microstructural composition of articular cartilage, and show great promise in clinical application.
出处
《临床放射学杂志》
CSCD
北大核心
2013年第9期1305-1310,共6页
Journal of Clinical Radiology
作者简介
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